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商品編號


60536



品牌


Bpsbioscience



公司


BPS Bioscience Inc.



公司分類(lèi)


Immunotherapy



Size

2 vials

商品信息













Background:
The binding of Programmed Cell Death Protein 1 (PD-1), a receptor expressed on activated Tcells, to its ligands, PD-L1 and PD-L2, negatively regulates immune responses. The PD-1 ligands are found on most cancers, and PD-1:PD-L1/2 interaction inhibits T cell activity and allows cancer cells to escape immune surveillance. The PD-1:PD-L1/2 pathway is also involved in regulating autoimmune responses, making these proteins promising therapeutic targets for a number of cancers, as well as multiple sclerosis, arthritis, lupus, and type I diabetes.




Description:
PD-L1 Cell Line:
Recombinant CHO-K1 cells constitutively expressing human PD-L1 (Programmed Cell Death 1 Ligand 1, CD274, B7 homolog 1 (B7- H1), GenBank accession # NM_014143) an engineered T cell receptor (TCR) activator.




Materials Required But Not Provided:
PD-1/ NFAT reporter-Jurkat cell line (BPS Cat. # 60535)
Assay medium: RPMI1640 + 10% FBS + 1% Penicillin/Streptomycin (Thaw Medium 2, BPS Cat. #60184)
Anti-PD-1 neutralizing antibody (BPS Cat. #71120)
Anti-PD-L1 neutralizing antibody (BPS Cat. #71213)
96-well tissue culture-treated white clear-bottom assay plate
One-Step luciferase assay system (BPS Cat. # 60690) or other luciferase reagents for measuring firefly luciferase activity
Luminometer




Synonym(s):
Programmed Cell Death 1 Ligand 1, PDL1, PD-L1, B7 homolog 1, B7H1, B7-H1, CD274, PDCD1L1




Host Cell line:
CHO-K1




Mycoplasma Testing:
The
PD-L1 Cell Line
has been screened using the PCR-based Venor?GeM Mycoplasma Detection kit (
Sigma-Aldrich
) to confirm the absence of Mycoplasma species.




Storage / St
ABI
lity:
Immediately upon receipt, store in liquid nitrogen.




Application(s):
Screen for activators or inhibitors of PD-1 signaling in a cellular context , screen PD-L1 antibodies for binding affinity ? Characterize the
BIOLOG
ical activity of PD-1 interactions with PD-L1




Notes:

Contact us for pricing.

License Disclosure
:Purchase of this cell line grants you with a 10-year license to use this cell line in your immediate laboratory, for research use only. This license does not permit you to share, distribute, sell, sublicense, or otherwise make the cell line available for use to other laboratories, departments, research institutions, hospitals, universities, or biotech companies. The license does not permit use of this cell line in humans or for therapeutic or drug use. The license does not permit modification of the cell line in any way. Inappropriate use or distribution of this cell line will result in revocation of the license and result in an immediate cease of sales and distribution of BPS products to your laboratory. BPS does not warrant the suit
ABI
lity of the cell line for any particular use, and does not accept any li
ABI
lity in connection with the handling or use of the cell line. Modifications of this cell line, transfer to another facility, or commercial use of the cells may require a separate license and additional fees; contact sales@bp
SBI
oscience.com for details. Publications using this cell line should reference BPS Bioscience, Inc., San Diego.




Scientific Category:
Immunotherapy




Product Type:
Cell Line




Data shown is lot-specific.
Contact us
for specific information on other lots.