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商品編號


CHI-HF-220ICAM1-C100



品牌


Adipogen



公司


Adipogen



公司分類(lèi)


Immunology



Size

100 ?g

商品信息


More Information



Product Details



Synonyms

ICAM1; Intercellular Adhesion Molecule 1



Product Type

Protein



Properties



Source/Host

CHO cells



Sequence

The extracellular domain of human CD54 [ICAM-1] (aa 28-480) is fused to the N-terminus of the Fc region of a mutant human IgG1.



Crossreactivity

Human



BIOLOG
ical Activity

Shows the
BIOLOG
ical function of the CD54 moiety and exerts a prolonged circulating half-life caused by the modified Fc domain.



Purity

≥98% (SDS-PAGE)



Endotoxin Content

<0.06eu mu;g="" protein="" (lal="" test;="" lonza).="">0.06eu>



Reconstitution

Reconstitute at 100μg/ml in sterile PBS.



Formulation

Lyophilized from 0.2μm-filtered solution in PBS.



Other Product Data

Non-lytic: Acts as a long lasting fusion protein which only binds to the receptor. Mutations to the complement (C1q) and FcgR I binding sites of the IgGs Fc fragment render the fusion proteins incapable of antibody directed cytotoxicity (ADCC) and complement directed cytotoxicity (CDC).
NCBI reference NP_000192.2: CD54 (human)



Declaration

Manufactured by Chimerigen.



Shipping and Handling



Shipping

BLUE ICE



Short Term Storage

+4°C



Long Term Storage

-20°C



Handling Advice

Avoid freeze/thaw cycles.



Use/St
ABI
lity

Stable for at least 1 year after receipt when stored at -20°C.
Working aliquots are stable for up to 3 months when stored at -20°C.



Documents



MSD
S

No



Product Specification Sheet



Datasheet


Download PDF





Intercellular Adhesion Molecule-1 (ICAM-1, CD54) binds the leukocyte integrins LFA-1 and Mac1. CD54 expression is weak on leukocytes, epithelial and resting endothelial cells, as well as some other cell types, but expression can be stimulated by IFN-γ, TNF-α, IL-1β and LPS. Soluble CD54 is found in a
BIOLOG
ically active form in serum, probably as a result of proteolytic cleavage from the cell surface, and is elevated in patients with various inflammatory syndromes such as septic shock, LAD, cancer and transplantation.