Sigma-Aldrich/Fmoc-Asp(O-2-PhiPr)-OH/8520860001/8520860001
多肽
商品編號
8520860001
品牌
西格瑪奧德里奇(Sigma-Aldrich)
公司
Merck & Co., Inc.
公司分類(lèi)
Chemistry
Size
8520860001
商品信息
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Synonym:
N-α-Fmoc-L-aspartic acid β-2-phenylisopropyl ester
CAS Number
200336-86-3
Linear Formula
C??H??NO?
Molecular Weight
473.52?g/mol
Properties:
Related Categories
Amino Acids & Derivatives,
Aspartic Acid,
Chemical
BIOLOG
y,
Chemical Synthesis,
Peptide Chemistry
Description:
Background information
Quasi-orthogonally-protected Asp derivative.
The 2-PhiPr group can be removed selectively in the presence of tBu-based protecting groups by treatment with 1% TFA in DCM [1], making this derivative an extremely useful tool for the preparation of cyclic peptides by Fmoc SPPS [2] or for library synthesis. For the on-resin synthesis of side-chain to side-chain lactam bridged peptides, the combination of Lys(Mtt) and Asp(O-2-PhiPr) is particularly advantageous since both side-chains can be simultaneously unmasked in a single step.
This derivative has also been used in solution to prepare bicyclic helix initiating peptides [3].
The product number for this product was previously 04-12-1200
.
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Safety:
HS Code?
2924 29 70
Storage class?
10 - 13 Other liquids and solids
WGK?
WGK 2 water endangering
產(chǎn)品貨號:1759.2