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商品編號


YIF-LF-PA0113



品牌


Adipogen



公司


Adipogen



公司分類(lèi)


Antibodies



Size

100 ?l

商品信息


More Information



Product Details



Synonyms

SYT6; SytVI; Synaptotagmin-6; Synaptotagmin VI



Product Type

Polyclonal Antibody



Properties



Immunogen/Antigen

Recombinant human His-SytVI protein purified from E. coli.



Application

Western Blot (1:2,000)
IHC-P
Immunoprecipitation not tested.



Crossreactivity

Human
Mouse
Rat



Formulation

Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.



Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.



Declaration

Manufactured by AbFrontier



Shipping and Handling



Shipping

BLUE ICE



Short Term Storage

+4°C



Long Term Storage

-20°C



Use/St
ABI
lity

Stable for at least 1 year after receipt when stored at -20°C.



Documents



MSD
S

No



Product Specification Sheet



Datasheet


Download PDF





Synaptotagmins (Syts) are a large gene family of synaptic vesicle integral membrane proteins. Syt functions as regulators of both exocytosis/endocytosis and is involved in neurotransmitter secretion from small secretory vesicles. 13 isoforms of Syt have been identified (SytI-XIII). SynaptotagminVI is localized to the endoplasmic reticulum and/or Golgi-like perinuclear compartment. It may be important for trafficking and calcium signaling as it is specially expressed in non-neuronal tissues. Also SytVI is present in the acrosomal region of mammalian spermatozoa. The cytosolic domain of SytVI can abrogate exocytosis by competing with the endogenous protein for essential interactions with the fusion machinery involved in a acrosomal exocytosis. May be involved in Ca2+-dependent exocytosis of secretory vesicles through Ca2+ and phospholipid binding to the C2 domain or may serve as Ca2+ sensors in the process of vesicular trafficking and exocytosis.


Product References
1) Michaut M, et al.(2001) Dev Biol. 235 (2);521-9. (General)
2) Mikoshiba K, et al.(1999) Chem Phys Lipids. 98(1-2);59-67. (General)
3) Butz S, et al.(1999) J Biol Chem. 274(26); 18290-6. (General)