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商品編號


AG-20T-0103-C100



品牌


Adipogen



公司


Adipogen



公司分類(lèi)


Antibodies



Size

100 ?g


商品信息


More Information



Product Details



Synonyms

Tyrosine Kinase with Ig and EGF Homology Domains-2; Angiopoietin-1 Receptor



Product Type

Monoclonal Antibody



Properties



Clone

tek9



Isotype

Mouse IgG1



Immunogen/Antigen

Recombinant human soluble extracellular domain of TIE-2.



Application


ELISA
:
(1-2μg/ml)
Flow Cytometry:
(2-5μg/ml)
Immunohistochemistry:
(frozen section)
Western Blot:
(2-5μg/ml)
Optimal conditions must be determined individually for each application.



Crossreactivity

Human



Specificity

Native human TIE-2 in
ELISA
experiments and on the surface of different human cell types.



Purity

Protein G purified.



Purity Detail

Protein G purified.



Formulation

Lyophilized.



Reconstitution

Centrifuge vial prior to opening. Reconstitute with sterile water to a concentration of 0.1-1.0mg/ml.



Shipping and Handling



Shipping

BLUE ICE



Short Term Storage

+4°C



Long Term Storage

-20°C



Handling Advice

After opening, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.



Use/St
ABI
lity

Stable for at least 6 months after receipt when stored at -20°C.



Documents



MSD
S


Download PDF



Product Specification Sheet



Datasheet


Download PDF





TIE-2 acts as cell-surface receptor for ANGPT1, ANGPT2 and ANGPT4 and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spre
ADI
ng, reorganization of the actin
Cytoskeleton
, but also maintenance of vascular quiescence. It has anti-inflammatory effects by preventing the leakage of proinflammatory plasma proteins and leukocytes from blood vessels. It is required for normal angiogenesis and heart development during embryogenesis and for post-natal hematopoiesis. After birth, it activates or inhibits angiogenesis, depending on the context. It inhibits angiogenesis and promotes vascular st
ABI
lity in quiescent vessels, where endothelial cells have tight contacts. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, le
ADI
ng to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1 and ultimately to the stimulation of sprouting angiogenesis.


Product References

Identification of proangiogenic TIE2-expressing monocytes (TEMs) in human peripheral blood and cancer: M.A. Venneri, et al.; Blood
109
, 5276 (2007)

Angiopoietin-2 Stimulation of Endothelial Cells Induces Integrin αvβ3 Internalization and Degradation: M. Thomas, et al.; J. Biol. Chem.
285
, 23842 (2010)