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商品編號


AG-20T-0310-C100



品牌


Adipogen



公司


Adipogen



公司分類(lèi)


Antibodies



Size

100 ?g

商品信息


More Information



Product Details



Synonyms

Toll-like Receptor 10; CD290



Product Type

Monoclonal Antibody



Properties



Clone

ABM3C85



Isotype

Mouse IgG2aκ



Immunogen/Antigen

Recombinant human TLR10 protein (aa 100-369).



Application


Western Blot:
(2-4μg/ml)
Optimal conditions must be determined individually for each application.



Crossreactivity

Human



Purity

Protein G purified.



Concentration

0.5mg/ml



Formulation

Liquid. In PBS containing 0.05% BSA and 0.05% sodium azide.



Accession Number

Q9BXR5



Shipping and Handling



Shipping

BLUE ICE



Short Term Storage

+4°C



Long Term Storage

-20°C



Handling Advice

After opening, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.



Use/St
ABI
lity

Stable for at least 1 year after receipt when stored at -20°C.
Stable for at least 6 months after receipt when stored at +4°C.



Documents



MSD
S

No



Product Specification Sheet



Datasheet


Download PDF





TLR10 (Toll-like Receptor10) is an orphan member of the TLR family and is the only pattern-recognition receptor without known ligand specificity and
BIOLOG
ical function. TLR10 is predominantly expressed in tissues rich in immune cells, such as spleen, lymph node, thymus, tonsil, and lung. This protein plays a role in innate immune responses following viral infection. Influenza virus infection increased TLR10 expression and TLR10 contributed to innate immune sensing of viral infection le
ADI
ng to cytokine induction, including proinflammatory cytokines and interferons. Blocking TLR10 by antago
NIST
ic antibodies enhanced proinflammatory cytokine production, including IL-1β specifically after exposure to TLR2 ligands. Like TLR1 and TLR6, TLR10 has also been shown to form a heterodimer complex with TLR2 during Helicobacter pylori infection and that it could be involved in the recognition of FSL-1, LPS and flagellin. TLR10 is an important innate immune sensor of viral infection with a role in innate immune defense and immunopathology following viral and bacterial pathogen infection.