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商品編號


AG-20T-0303-C100



品牌


Adipogen



公司


Adipogen



公司分類(lèi)


Antibodies



Size

100 ?g

商品信息


More Information



Product Details



Synonyms

Toll-like Receptor 4; TOLL; hToll; CD284; ARMD10



Product Type

Monoclonal Antibody



Properties



Clone

ABM19C4



Isotype

Mouse IgG2bκ



Immunogen/Antigen

Recombinant human TLR4 protein (aa 45-320).



Application


Immunohistochemistry:
(5μg/ml; paraffin sections)

Flow Cytometry:
For FACS use conjugated versions of AG-20T-0303.

Western Blot:
(2-4μg/ml)
Optimal conditions must be determined individually for each application.



Crossreactivity

Human



Specificity

Recognizes human TLR4.



Purity

Protein G purified.



Concentration

0.5mg/ml



Formulation

Liquid. In PBS containing 0.05% BSA and 0.05% sodium azide.



Accession Number

O00206



Shipping and Handling



Shipping

BLUE ICE



Short Term Storage

+4°C



Long Term Storage

-20°C



Handling Advice

After opening, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.



Use/St
ABI
lity

Stable for at least 1 year after receipt when stored at -20°C.
Stable for at least 6 months after receipt when stored at +4°C.



Documents



MSD
S

No



Product Specification Sheet



Datasheet


Download PDF





TLR4 (Toll-like Receptor 4) is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. It was the first TLR identified TLR in mammals and most studied member of the TLR family. TLR4 recognizes the active lipid A component of lipopolysaccharide (LPS) from Gram-negative bacteria in conjunction with LY96 (also referred to MD-2), CD14 and LPS-binding protein (LBP) and consequently mediates the innate immune response to bacterial lipopolysaccharide (LPS). Additionally, it is also involved in LPS-independent responses triggered by endogenous DMAPs, such as heat shock proteins (HSPs) or HMGB1. TLR4 signals via MYD88, TIRAP and TRAF6, le
ADI
ng to NF-κB activation, cytokine secretion and the inflammatory response in various cell types. In complex with TLR6, it was shown to promote sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-β 42. TLR4-mediated inflammation, triggered by exogenous or endogenous ligands, is involved in several acute and chronic diseases, having a pivotal role as amplifier of the inflammatory response. The potency with which this TLR activates inflammatory pathways makes it an ideal target for therapeutic intervention and adjuvant development. A broad range of clinical studies have examined the adjuvant activity of TLR4 activators in vaccines against infectious and tumor antigens.