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商品編號


AG-20T-0304-C100



品牌


Adipogen



公司


Adipogen



公司分類(lèi)


Antibodies



Size

100 ?g

商品信息


More Information



Product Details



Synonyms

Toll-like Receptor 5; Toll/interleukin-1 Receptor-like Protein 3; TIL3; MELIOS; SLE1; SLEB1



Product Type

Monoclonal Antibody



Properties



Clone

ABM22G1



Isotype

Mouse IgG2aκ



Immunogen/Antigen

Recombinant human TLR5 protein (aa 261-420).



Application


Immunohistochemistry:
(10μg/ml; paraffin sections)
Flow Cytometry:
(0.5μg/10
6
cells)
Optimal conditions must be determined individually for each application.



Crossreactivity

Human



Specificity

Recognizes human TLR5.



Purity

Protein G purified.



Concentration

0.5mg/ml



Formulation

Liquid. In PBS containing 0.05% BSA and 0.05% sodium azide.



Accession Number

O60602



Shipping and Handling



Shipping

BLUE ICE



Short Term Storage

+4°C



Long Term Storage

-20°C



Handling Advice

After opening, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.



Use/St
ABI
lity

Stable for at least 1 year after receipt when stored at -20°C.
Stable for at least 6 months after receipt when stored at +4°C.



Documents



MSD
S

No



Product Specification Sheet



Datasheet


Download PDF





TLR5 (Toll-like Receptor 5) is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLR5 recognizes bacterial flagellin, a principal component of bacterial flagella and a virulence factor, via a conserved region within flagellin, the D1 portion/domain. Binding of flagellin induces the dimerization of TLR5, which in turn recruits MyD88. The recruitment of MyD88 leads to subsequent activation of IRAK4, IRAK1, TRAF6 and eventually IκB kinases. Activation of IκB kinases mobilizes the nuclear factor NF-κB and stimulates many downstream gene expressions, which initiate the canonical proinflammatory pathway, including TNF-α production. TLR5 may play a role in inflammatory bowel disease (I
BD
). Lower levels of TLR5 expression have been found in patients exhibiting moderate to severe ulcerative colitis (UC). TLR5 is suggested to be poss
IBL
y involved in HPV induced inflammation and subsequent cervical neoplasia formation. It has been reported that TLR5 expression is detected in both ovarian epithelium and ovarian cancer cell lines, suggesting a poss
IBL
e role of TLR5 in inflammation induced ovarian cancer onset. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus and susceptibility to legionnaire disease, highlighting the importance of TLR5 in microbial recognition particularly at the mucosal surface.