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商品編號


YIF-LF-MA0210



品牌


Adipogen



公司


Adipogen



公司分類(lèi)


Antibodies



Size

100 ?l

商品信息


More Information



Product Details



Synonyms

TNF; TNFA



Product Type

Monoclonal Antibody



Properties



Clone

6C10



Isotype

Mouse IgG1 κ



Immunogen/Antigen

Recombinant human GFP-TNF-α protein purified from E. coli.



Application


ELISA
Western Blot (1:2,000)



Crossreactivity

Human



Purity Detail

Ammonium sulfate precipitation.



Formulation

Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.



Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.



Declaration

Manufactured by AbFrontier



Shipping and Handling



Shipping

BLUE ICE



Short Term Storage

+4°C



Long Term Storage

-20°C



Use/St
ABI
lity

Stable for at least 1 year after receipt when stored at -20°C.



Documents



MSD
S

No



Product Specification Sheet



Datasheet


Download PDF





Tumor necrosis factor (TNF)-α is an important cytokine in the innate immune response produced by macrophages, neutrophils, fibroblasts, keratinocytes, NK cells, T and B cells, and tumour cells. TNF-α mediates host responses in acute and chronic inflammatory conditions, and is a mediator of protection from infection and malignancy. TNF-α causes apoptotic cell death, cellular proliferation, differentiation, inflammation, tum
Origen
esis, and viral replication. TNF-α is initially produced as a
BIOLOG
ically active 26 kDa transmembrane protein, which is subsequently cleaved, principally by TNF-α-converting enzyme (TACE), to release the 17kDa free protein. These proteins are arranged in
BIOLOG
ically active homotrimers that act on the ubiquitously expressed TNF-α receptors 1 and 2 (TNFR1 and TNFR2). These 17 kDa TNF protomers are composed of two antiparallel β-pleated sheets with antiparallel β-strands, forming a 'jelly roll' β-structure, typical for the TNF family. TNF-R1 is constitutively expressed in most tissues, and can be fully activated by both the membrane-bound and soluble trimeric forms of TNF, while TNF-R2 is only found in cells of the immune system and respond to the membrane-bound form of the TNF homotrimer. Although their extracellular domains share structural and functional homology, their intracellular domains are distinct. Tumor necrosis factor promotes the inflammatory response, which in turn causes many of the clinical problems associated with autoimmune disorders such as rheumatoid arthritis, ankylosing spondylitis, Crohn's disease, psoriasis and refractory asthma. These disorders are sometimes treated by using TNF inhibitors such as infliximab (Remicade) or adalimumab (Humira). Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation.


Product References
1) Berry M, et al. (2007) Curr Opin Pharmacol. 7(3):279-282. (General)
2) Anderson GM, et al. (2004) Curr Opin Pharmacol. 4(4):314-320. (General)
3) Pall
ADI
no MA, et al. (2003) Nature Reviews Drug Discovery. 2:736-746. (General)