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商品編號


YIF-LF-PA0023



品牌


Adipogen



公司


Adipogen



公司分類(lèi)


Antibodies



Size

100 ?l

商品信息


More Information



Product Details



Synonyms

TR; TXNRD1; GRIM12; GRIM-12; EC=1.8.1.9; Thioredoxin Reductase TR1; Thioredoxin Reductase 1; Cytoplasmic; KM-102-derived Reductase-like Factor; Gene Associated with Retinoic and IFN-induced Mortality 12 Protein



Product Type

Polyclonal Antibody



Properties



Immunogen/Antigen

Recombinant human protein purified from E. coli.



Application

Western Blot (1:2,000)



Crossreactivity

Human



Purity Detail

Protein A purified.



Concentration

0.5 mg/ml



Formulation

Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.



Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.



Declaration

Manufactured by AbFrontier



Shipping and Handling



Shipping

BLUE ICE



Short Term Storage

+4°C



Long Term Storage

-20°C



Use/St
ABI
lity

Stable for at least 1 year after receipt when stored at -20°C.



Documents



MSD
S

No



Product Specification Sheet



Datasheet


Download PDF





The mammalian thioredoxin reductases (TrxRs) are a family of selenocysteine-containing pyridine nucleotide-disulfide oxidoreductases. All the mammalian TrxRs are homologous to glutathione reductase with respect to primary structure including the conserved redox catalytic site (-Cys-Val-Asn-Val-Gly-Cys-) but distinctively with a C-terminal extension containing a catalytically active penultimate selenocysteine (SeCys) residue in the conserved sequence(-Gly-Cys-SeCys-Gly). TrxR is homodimeric protein in which each monomer includes an FAD prosthetic group, a NADPH binding site and a redox catalytic site. Electrons are transferred from NADPH via FAD and the active-site disulfide to C-terminal SeCys-containing redox center, which then reduces the substrate like thioredoxin. The members of TrxR family are 55 - 58 kilodalton in molecular size and composed of three isoforms including cytosolic TrxR1, mitochondrial TrxR2, and TrxR3, known as Trx and GSSG reductase (TGR). TrxR plays a key role in protection of cells against oxidative stress and redox-regulatory mechanism of transcription factors and various
BIOLOG
ical phenomena (1). Isoform 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, le
ADI
ng to formation of cell membrane protrusions. Isoform 4 enhances the transcriptional activity of estrogen receptors α and β while isoform 5 enhances the transcriptional activity of the β receptor only. Isoform 5 also mediates cell death induced by a combination of interferon-β and retinoic acid.


Product References
1) Mustacich, D. and Powis,G. (2000) Biochem J. 15. 346 Pt 1:1-8. (General)