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商品編號


AG-20B-0029-C100



品牌


Adipogen



公司


Adipogen



公司分類(lèi)


Antibodies



Size

100 ?g



商品信息


More Information



Product Details



Synonyms

TRAIL Receptor 3; DcR1; TRID; TNFRSF10C; CD263



Product Type

Monoclonal Antibody



Properties



Clone

TR3.06



Isotype

Mouse IgG1



Source/Host

Purified from concentrated hybridoma tissue culture supernatant.



Immunogen/Antigen

Recombinant human TRAIL-R3 (DcR1).



Application


Flow Cytometry

Immunohistochemistry:
(paraffin sections) (20μg/ml)
Optimal conditions must be determined individually for each application.




Crossreactivity

Human



Specificity


Recognizes human TRAIL-R3. Does not cross-react with human TRAIL-R1, -R2 or -R4.




Purity

≥95% (SDS-PAGE)



Purity Detail

Protein G-affinity purified.



Concentration

1mg/ml



Formulation

Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.



Other Product Data


Specially developed for the immunohistochemical detection of TRAIL-R3 in paraffin embedded tissue. Has been shown to detect TRAIL-R3 expressed at endogenous levels in paraffin-embedded tissue in different mammary carcinoma tissues.
For IHC (paraffin sections) TRAIL-R3 specific staining protocol (see PDF on web).
UniProt link O14798: human TRAIL-R3




Shipping and Handling



Shipping

BLUE ICE



Short Term Storage

+4°C



Long Term Storage

-20°C



Handling Advice

After opening, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.



Use/St
ABI
lity

Stable for at least 1 year after receipt when stored at -20°C.



Documents



Protocols


Download PDF



MSD
S


Download PDF



Product Specification Sheet



Datasheet


Download PDF






TRAIL-R3 is a receptor for the cytotoxic ligand TRAIL. It lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. Protects cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand.



Product References

Troglitazone-mediated sensitization to TRAILinduced apoptosis is regulated by proteasomedependent degradation of FLIP and ERK1/2- dependent phosphorylation of BAD: K. Grund, et al.; Cancer Biol. Ther.
7,
1982 (2008)

Prognostic significance of tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor expression in patients with breast cancer: T. M. Ganten, et al.; J. Mol. Med.
87,
995 (2009)

Prognostic Value of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) and TRAIL Receptors in Renal Cell Cancer: S. Macher-Goeppinger, et al.; Clin. Cancer Res.
15,
650 (2009)

Cytosolic and nuclear caspase-8 have opposite impact on survival after liver resection for hepatocellular carcinoma: R. Koschny, et al.; BMC Cancer
13,
532 (2013)

IAPs cause resistance to TRAIL-dependent apoptosis in follicular 1 thyroid cancer: T.A. Werner, et al.; Endocr. Relat. Cancer
17,
?0479 (2018)