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商品編號


YIF-LF-MA0241



品牌


Adipogen



公司


Adipogen



公司分類(lèi)


Antibodies



Size

100 ?l

商品信息


More Information



Product Details



Synonyms

TF; PRO1400; Transferrin; Siderophilin;
SERO
transferrin; β-1 Metal-binding Globulin



Product Type

Monoclonal Antibody



Properties



Clone

3C11



Isotype

Mouse IgG2b κ



Immunogen/Antigen

Protein purified from human plasma.



Application

Western Blot (1:5,000)



Crossreactivity

Human



Purity Detail

Ammonium sulfate precipitation.



Formulation

Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.



Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.



Declaration

Manufactured by AbFrontier



Shipping and Handling



Shipping

BLUE ICE



Short Term Storage

+4°C



Long Term Storage

-20°C



Use/St
ABI
lity

Stable for at least 1 year after receipt when stored at -20°C.



Documents



MSD
S

No



Product Specification Sheet



Datasheet


Download PDF





Transferrin (Tf) is a blood plasma protein for iron delivery. Transferrin functions to deliver iron to cells via a receptor-mediated endocytotic process as well as to remove toxic free iron from the blood and to provide an antibacterial, low-iron environment. Tf protein contains 679 amino acid residues and has a molecular weight of ~79 kD, having 2 specific high affinity Fe(III) binding sites. The molecule is st
ABI
lized by 19 intra-chain disulfide bonds and is protected by three carbohydrate side chains. Although iron bound to transferrin is less than 0.1% (4 mg) of the total body iron, it is the most important iron pool, with the highest rate of turnover (25 mg/24 h). When a Tf protein loaded with iron encounters a transferrin receptor (TfR) on the surface of a cell it binds to it and is consequently transported into the cell by endosomes. ATP-dependent proton pumps then force H+ ions into the endosomes reducing the pH to 5.5, thus promoting iron release and conformational change of the receptor enabling apo-transferrin to remain bound. The binding characteristics of the apo-Tf–TfR complex are such that the apo-Tf is released only once the complex reaches the cell surface. Cells expressing large amounts of TfR are correspondingly competent in securing iron from Tf. Rapidly proliferating cells, as in malignancy, generally express TfR1 abundantly. Several studies have shown a link between Tf polymorphism and susceptibility to disease. These include the rare autosomal recessive disorder atransferrinemia, cardiovascular disease (CVD) and Alzheimer’s disease. Transferrins are iron binding transport proteins which can bind two Fe3+ ions in association with the binding of an anion, usually bicarbonate. It is respons
IBL
e for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.


Product References
1) Wally J. and Buchanan SK. (2007) Biometals. 20(3-4):249-262. (General)
2) Gomme PT. et al. (2005) Drug Discov Today. 10(4):267-273. (General)
3) Aisen P. (2004) Int J Biochem Cell Biol. 36(11) :2137-2143. (General)