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商品編號


AG-40T-0040-C010



品牌


Adipogen



公司


Adipogen



公司分類(lèi)


Proteins



Size

10 ?g


商品信息


More Information



Product Details



Synonyms

Basic Fibroblast Growth Factor; bFGF; Heparin Binding Growth Factor-2; HBGF-2



Product Type

Protein



Properties



Source/Host

E. coli



Sequence

Human FGF-2 (153aa).



Crossreactivity

Human



BIOLOG
ical Activity

The ED
50
for stimulation of cell proliferation in human umbilical vein endothelial cells by human FGF-2 (basic) has been determined to be in the range of 0.1-2 ng/ml.



MW

~16.5kDa



Purity

≥98% (SDS-PAGE)



Endotoxin Content

<0.1ng g="" protein.="">0.1ng>



Reconstitution

Reconstitute with sterile water containing at least 0.1% human or bovine serum albumin to a concentration not lower than 50?g/ml.



Formulation

Lyophilized. Contains PBS.



Other Product Data

UniProt link P09038: FGF-2 (human)



Shipping and Handling



Shipping

BLUE ICE



Short Term Storage

+4°C



Long Term Storage

-20°C



Handling Advice

After reconstitution, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.



Use/St
ABI
lity

Stable for at least 6 months after receipt when stored at -20°C.



Documents



MSD
S


Download PDF



Product Specification Sheet



Datasheet


Download PDF





FGF-2 plays an important role in the regulation of angiogenesis, cell survival, cell division, wound healing and tissue repair, embryonic development, cell differentiation and cell migration, neuronal function and neural degeneration. It functions as potent mitogen
in vitro
.


Product References

Loss of Akt activity increases circulating soluble endoglin release in preeclampsia: identification of inter-dependency between Akt-1 and heme oxygenase-1: M.J. Cudmore, et al.; Europ. Heart J.
33
, 1150 (2012)

Endothelial Heparan Sulfate 6-O-sulfation Levels Regulate Angiogenic Responses of Endothelial Cells to FGF2 and VEGF: C. Ferreras, et al.; J. Biol. Chem.
287
, 36132 (2012)