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商品編號


AG-40B-0127-3010



品牌


Adipogen



公司


Adipogen



公司分類(lèi)


Proteins



Size

3 x 10 ?g


商品信息


More Information



Product Details



Synonyms

FliC (TLR5 Mutant)



Product Type

Protein



Properties



Source/Host

E. coli



Sequence

The native flagellin [FliC] from Salmonella enterica
SERO
var Typhimurium strain
ATCC
14028 (aa 1-495) contains a substitution of amino acids 90-97 required for TLR5 signaling by a motif from a non-signaling flagellin and is fused at the N-terminus to a His-tag.



Crossreactivity

Human
Mouse



Specificity

Not detected by human and mouse TLR5 (Toll-like receptor 5).



BIOLOG
ical Activity

Does not activate TLR5 in human epithelial cell assays based on NF-κB luciferase fusions,
in vivo
on expression of CCL20 or IL-6. It can be used as negative control for TLR5 signaling assays.



Purity

≥95% (SDS-PAGE)



Endotoxin Content

<0.01eu mu;g="" purified="" protein="" (lal="" test;="" lonza).="">0.01eu>



Concentration

0.1mg/ml after reconstitution.



Reconstitution

Reconstitute with 100μl sterile water.



Formulation

Lyophilized. Contains PBS.



Other Product Data

NCBI link NP_460912.1: Flagellin [Salmonella enterica subsp. enterica
SERO
var Typhimurium str. LT2]



Shipping and Handling



Shipping

BLUE ICE



Short Term Storage

+4°C



Long Term Storage

-20°C



Handling Advice

After reconstitution, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.



Use/St
ABI
lity

Stable for at least 6 months after receipt when stored at -20°C.



Documents



MSD
S


Download PDF



Product Specification Sheet



Datasheet


Download PDF





Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. It activates the innate immune system through the receptor Toll-like Receptor 5 (TLR5) or the intracellular NLRC4 protein. The Flagellin (TLR5 Mutant) (rec.) cannot be detected by human and mouse TLR5. It has not been tested on NLRC4.