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商品編號


AG-40B-0124-C010



品牌


Adipogen



公司


Adipogen



公司分類(lèi)


Proteins



Size

10 ?g


商品信息


More Information



Product Details



Synonyms

Fibronectin Type III Domain-containing Protein 4; Fibronectin Type III Repeat-containing Protein 1



Product Type

Protein



Properties



Source/Host

E. coli



Sequence

FNDC4 (extracellular domain, human (aa 45-167) / mouse (aa 41-163)) is untagged. FNDC4 extracellular domain has 100% identity between human, mouse, rat, dog and monkey.



Crossreactivity

Dog
Human
Monkey
Mouse
Rat



MW

~16kDa



Purity

≥95% (SDS-PAGE)



Endotoxin Content

<0.01eu mu;g="" purified="" protein="" (lal="" test;="" lonza).="">0.01eu>



Concentration

After reconstitution:
for 10?g size:
0.1mg/ml
for 50?g size:
1 mg/ml



Reconstitution


10?g size:
Reconstitute with 100?l sterile water.
50?g size:
Reconstitute with 50?l sterile water.



Formulation

Lyophilized. Contains PBS.



Other Product Data

Uni-Prot link Q9H6D8: FNDC4



Shipping and Handling



Shipping

BLUE ICE



Short Term Storage

+4°C



Long Term Storage

-20°C



Handling Advice

After reconstitution, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
PBS containing at least 0.1% BSA should be used for further dilutions.



Use/St
ABI
lity

Stable for at least 6 months after receipt when stored at -20°C.



Documents



MSD
S


Download PDF



Product Specification Sheet



Datasheet


Download PDF





Irisin is a recently described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin activates beige fat cells (beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone irisin). Irisin is cleaved from the type I membrane protein FNDC5 and improves systemic metabolism by increasing energy expenditure. FNDC4 is an ortholog of FNDC5 with 50% identity and 86% similarity compared to Irisin. FNDC4 as well as FNDC5 are extremely well conserved between species. The human FNDC4 gene is highly enriched in liver, brain tissue and
ADI
pocytes. FNDC4 is a factor with direct therapeutic potential in inflammatory bowel disease and poss
IBL
y other inflammatory diseases.