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商品編號


AG-40B-0153-3010



品牌


Adipogen



公司


Adipogen



公司分類(lèi)


Proteins



Size

3 x 10 ?g


商品信息


More Information



Product Details



Synonyms

Fibronectin Type III Domain-containing Protein 5; Fibronectin Type III Repeat-containing Protein 2.



Product Type

Protein



Properties



Source/Host

HEK 293 cells



Sequence

FNDC5 (extracellular domain) (human, aa 32-152 / mouse, aa 29-149) is fused at the C-terminus to the Fc portion of human IgG1. FNDC5 (extracellular domain) has 100% identity between mouse, rat and human.



Crossreactivity

Human
Mouse
Rat



MW

~52kDa



Purity

≥95% (SDS-PAGE)



Endotoxin Content

<0.01eu mu;g="" purified="" protein="" (lal="" test;="" lonza).="">0.01eu>



Concentration

0.1mg/ml after reconstitution.



Reconstitution

Reconstitute with 100μl sterile water.



Formulation

Lyophilized. Contains PBS.



Other Product Data

Uni-Prot link Q8NAU1: FNDC5



Shipping and Handling



Shipping

BLUE ICE



Short Term Storage

+4°C



Long Term Storage

-20°C



Handling Advice

After reconstitution, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
PBS containing at least 0.1% BSA should be used for further dilutions.



Use/St
ABI
lity

Stable for at least 6 months after receipt when stored at -20°C.



Documents



MSD
S


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Product Specification Sheet



Datasheet


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Irisin is a recently described exercise and PGC1-α-induced myokine secreted by skeletal muscle in mice and humans. Irisin has been shown to induce browning of white
ADI
pose tissue, but this role has been questioned and a new function in the control of mass and strength of cortical bone has been reported. The membrane fibronectin type III domain containing protein 5 (FNDC5) can be cleaved by an unknown protease to release the Irisin protein (aa 32-143 for human) and potentially also the FNDC5 (extracellular domain, aa 32-153 for human).