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商品編號


AG-40B-0133-3050



品牌


Adipogen



公司


Adipogen



公司分類(lèi)


Proteins



Size

3 x 50 ?g


商品信息


More Information



Product Details



Synonyms

FzE5; Fz-5; hFz5



Product Type

Protein



Properties



Source/Host

HEK 293 cells



Sequence

The cysteine-rich domain (CRD) of human Frizzled-5 (aa 27-180) is fused at the C-terminus to the Fc portion of human IgG1.



Crossreactivity

Human
Mouse



Specificity

Binds?to human and mouse Wnt3a.



BIOLOG
ical Activity

Inhibits Wnt3a activation in a stoechiometric manner.



MW

~50kDa (SDS-PAGE)



Purity

≥95% (SDS-PAGE)



Endotoxin Content

<0.01eu mu;g="" purified="" protein="" (lal="" test;="" lonza).="">0.01eu>



Concentration

1mg/ml after reconstitution.



Reconstitution

Reconstitute with 50μl sterile water.



Formulation

Lyophilized. Contains PBS.



Other Product Data

Uni-Prot link Q13467: Frizzled-5 (human)



Shipping and Handling



Shipping

BLUE ICE



Short Term Storage

+4°C



Long Term Storage

-20°C



Handling Advice

After reconstitution, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
PBS containing at least 0.1% BSA should be used for further dilutions.



Use/St
ABI
lity

Stable for at least 6 months after receipt when stored at -20°C.



Documents



MSD
S


Download PDF



Product Specification Sheet



Datasheet


Download PDF





Wnts are lipid-modified morphogens that control many processes during development, stem cell maintenance and homeostasis and their aberrant regulation has been linked to diseases in man including diabetes, neurodegeneration and cancer. Three distinct receptor families mediate Wnt signaling: Fzs, the single-pass LRP5/6 co-receptors and the atypical tyrosine kinase receptors Ror2 and Ryk. Frizzled proteins can activate canonical Wnt/β-catenin signaling as well as non-canonical pathways (Wnt/Ca
2+
pathways and planar cell polarity). The cysteine-rich domain (CRD) of the frizzled receptors situated on the extracellular part of the receptor is sufficient to bind the Wnt ligands.