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商品編號


AG-40B-0028-3050



品牌


Adipogen



公司


Adipogen



公司分類(lèi)


Proteins



Size

3 x 50 ?g


商品信息


More Information



Product Details



Synonyms

Tumor Necrosis Factor Receptor Superfamily Member 18; Glucocorticoid-induced TNFR-related Protein; CD357; TNFRSF18; AITR; Activation-induc
IBL
e TNFR Family Receptor



Product Type

Protein



Properties



Source/Host

HEK 293 cells



Sequence

Human GITR (aa 26-162) is fused at the C-terminus to the Fc portion of human IgG1.



Crossreactivity

Human



Specificity

Binds to human GITRL.



MW

~48kDa (SDS-PAGE)



Purity

≥95% (SDS-PAGE)



Endotoxin Content

<0.01eu mu;g="" purified="" protein="" (lal="" test;="" lonza).="">0.01eu>



Concentration

1mg/ml after reconstitution.



Reconstitution

Reconstitute with 50μl sterile water.



Formulation

Lyophilized. Contains PBS.



Other Product Data

UniProt link Q9Y5U5
GITR (human)




Shipping and Handling



Shipping

BLUE ICE



Short Term Storage

+4°C



Long Term Storage

-20°C



Handling Advice

After reconstitution, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
PBS containing at least 0.1% BSA should be used for further dilutions.



Use/St
ABI
lity

Stable for at least 6 months after receipt when stored at -20°C.



Documents



MSD
S


Download PDF



Product Specification Sheet



Datasheet


Download PDF





GITR (Glucocorticoid-induced TNF receptor) is the receptor for TNFSF18. It is involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T cell receptor-mediated cell death. GITR serves as a negative regulator for NK cell activation. It mediates NF-κB activation via the TRAF2/NIK pathway.