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商品編號


AG-40A-0008-C050



品牌


Adipogen



公司


Adipogen



公司分類(lèi)


Proteins



Size

50 ?g


商品信息


More Information



Product Details



Synonyms

Glucocorticoid-induced TNF Receptor Ligand; AITRL; Activation-induc
IBL
e TNF-related Ligand; TNFSF18



Product Type

Protein



Properties



Source/Host

HEK 293 cells



Sequence

The extracellular domain of mouse GITRL (aa 45-173) is fused at the N-terminus to a FLAG
?
-tag.



Crossreactivity

Mouse



Specificity

Binds to mouse GITR.



BIOLOG
ical Activity

Induces GITR-mediated NF-κB activation in HEK 293 cells.



MW

~22kDa (SDS-PAGE)



Purity

≥90% (SDS-PAGE)



Endotoxin Content

<0.1eu mu;g="" purified="" protein="" (lal="" test;="" lonza).="">0.1eu>



Concentration

0.5mg/ml



Formulation

Liquid. 0.2μm-filtered solution in 10mM glycine, pH 10.0.



Other Product Data


UniProt link Q7TS55: GITR Ligand (mouse)

FLAG is a registered trademark of
Sigma-Aldrich
Co.




Shipping and Handling



Shipping

BLUE ICE



Short Term Storage

+4°C



Long Term Storage

-20°C



Handling Advice

After opening, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.



Use/St
ABI
lity

Working aliquots are stable for up to 3 months when stored at -20°C.



Documents



MSD
S


Download PDF



Product Specification Sheet



Datasheet


Download PDF





GITRL (Glucocorticoid-induced TNF receptor ligand) is expressed on dendritic cells (DC), monocytes, macrophages, B cells, activated T cells, endothelial cells, osteoclasts and various healthy non-lymphoid tissues (e.g. testis). GITRL is constitutively expressed and released as soluble form by solid tumors and various hematopoietic malignancies. GITRL causes differentiation of osteoclasts, activation of macrophages, but also alteration of carcinoma and leukemia cells and influences apoptosis. Binding to GITR is important in regulating T cell proliferation and TCR-mediated apoptosis. GITRL is implicated in development of autoimmune diseases and in the immune response against infectious pathogens and tumors.


Product References
Identification of a ligand for glucocorticoid-induced tumor necrosis factor receptor constitutively expressed in dendritic cells: K.Y. Yu, et al.; BBRC
310,
433 (2003)