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商品編號


AG-40T-0042-C005



品牌


Adipogen



公司


Adipogen



公司分類(lèi)


Proteins



Size

5 ?g


商品信息


More Information



Product Details



Synonyms

Hepatocyte Growth Factor; Hepatopoietin-A; Scatter Factor



Product Type

Protein



Properties



Source/Host

Sf9 cells



Sequence

Human HGF (692aa).



Crossreactivity

Human



BIOLOG
ical Activity

The activity was assayed for scattering activity in the MDCK cell assay. The ED50 for this effect is typically at 1.0-5.0ng/ml.



MW

~78kDa



Purity

≥90% (SDS-PAGE)



Reconstitution

HGF is soluble in acetic acid (50mM), water and most aqueous buffers and can be reconstituted to a concentration of 100?g/ml. Further dilutions should be made into buffer containing protein or medium containing serum.



Formulation

Lyophilized.



Other Product Data

UniProt link P14210: HGF (human)



Shipping and Handling



Shipping

BLUE ICE



Short Term Storage

+4°C



Long Term Storage

-20°C



Handling Advice

After reconstitution, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.



Use/St
ABI
lity

Stable for at least 6 months after receipt when stored at -20°C.



Documents



MSD
S


Download PDF



Product Specification Sheet



Datasheet


Download PDF





Human hepatocyte growth factor (HGF) is synthesized as a
BIOLOG
ically inactive single chain precursor, which is cleaved by a specific, extracellular serum serine protease to a fully active heterodimer. It stimulates the motility and invasion of several cancer cell types and can induce angiogenesis. All
BIOLOG
ical responses induced by HGF are elicited by binding to its transmembrane tyrosine kinase receptor. HGF function is essential for normal development. Knockout studies have demonstrated that both ligand and receptor deficient mice display an embryonic lethal phenotype. HGF synergizes with basic FGF in the induction of angiogenesis. HGF is a potent mitogen for mature parenchymal hepatocyte cells and is a pleiotrophic cytokine. It acts as growth factor for a broad spectrum of tissues and cell types. It has no detectable protease activity. It is an activating ligand for the receptor tyrosine kinase MET by binding and promoting its dimerization.


Product References
Functional analysis of HGF/MET signaling and aberrant HGF-activator expression in diffuse large B-cell lymphoma: EP. Tjin, et al.; Blood
107
, 760 (2006)