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商品編號


CHI-HR-200HMGB1-C025



品牌


Adipogen



公司


Adipogen



公司分類(lèi)


Proteins



Size

25 ?g

商品信息


More Information



Product Details



Synonyms

High Mobility Group Protein B1



Product Type

Protein



Properties



Source/Host

E. coli



Sequence

Human HMGB1 (aa 24-215) is fused at the N-terminus to a His-tag.



Crossreactivity

Human



Purity

≥90% (SDS-PAGE)



Endotoxin Content

<0.1eu mu;g="" protein="" (lal="" test;="" lonza).="">0.1eu>



Reconstitution

Reconstituted in sterile H
2
O not less than 100μg/ml, which can then be further diluted in other aqueous solutions.



Formulation

Lyophilized from a concentrated sterile solution containing 50mM Tris-Hcl buffer (pH 8.0) and 100mM NaCl.



Other Product Data

NCBI reference NP_002119.1: HMGB1 (human)



Declaration

Manufactured by Chimerigen.



Shipping and Handling



Shipping

BLUE ICE



Short Term Storage

+4°C



Long Term Storage

-20°C



Handling Advice

Avoid freeze/thaw cycles.



Use/St
ABI
lity

Stable for at least 1 year after receipt when stored at -20°C.
Working aliquots are stable for up to 3 months when stored at -20°C.



Documents



MSD
S

No



Product Specification Sheet



Datasheet


Download PDF





HMGB1 was originally discovered as an essential DNA-binding protein for regulating p53, NF-κB and other important proteins. It is secreted from activated dentric cells, macrophage and nectrotic cells, and acts as a ligand for RAGE, TLR-2 and TLR-4 expressed on surrounding cells. As a result, HMGB1 activates Rac, CDC42 and NF-κB inducing localized innate immunity of damaged tissue, tissue regeneration by recruitment of stem cells and hemostasis by induction of tissue factor expression. HMGB1 is also causative agent of various diseases as it causes localized inflammation such as arteriosclerosis, chronic rheumatoid arthritis and nephritis.