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商品編號


AG-40A-0191-C010



品牌


Adipogen



公司


Adipogen



公司分類(lèi)


Proteins



Size

10 ?g


商品信息


More Information



Product Details



Synonyms

Interleukin-38; Interleukin-1 Family Member 10 theta; IL-1F10; FIL1 theta; FKSG75; IL-1HY2; IL1-theta; Interleukin-1 HY2; Interleukin-1 Receptor Antago
NIST
FKSG75



Product Type

Protein



Properties



Source/Host

E. coli



Sequence

Human IL-38 (aa 1-152) is fused at the C-terminus to a His-tag.



Crossreactivity

Human



MW

~18kDa (SDS-PAGE)



Purity

≥95% (SDS-PAGE)



Purity Detail

Purified using Ni-NTA column and FPLC.



Endotoxin Content

<1eu g="" purified="" protein="" (lal="" test;="" lonza).="">1eu>



Reconstitution

Reconstitute in distilled water.



Formulation

Lyophilized from 0.2μm-filtered solution in 55mM TRIS-Cl, pH 8.2, containing 150mM NaCl.



Other Product Data

UniProt link Q8WWZ1:
IL-38 (human)




Shipping and Handling



Shipping

BLUE ICE



Short Term Storage

+4°C



Long Term Storage

-20°C



Handling Advice

Avoid freeze/thaw cycles.



Use/St
ABI
lity

Working aliquots are stable for up to 3 months when stored at -20°C.



Documents



MSD
S


Download PDF



Product Specification Sheet



Datasheet


Download PDF





IL-38 (IL-1F10) mRNA is expressed in heart, placenta, fetal liver, spleen, thymus and tonsil. The expression in a variety of immune tissues and similarity to IL-1Ra suggest a role of IL-1F10 in the inflammatory response. It has been reported that removal of the N-terminus domain of the interleukins of the IL-1F family such as IL-1F5 / 6 / 8 or 9 (also called IL-36Ra, IL-36α, IL-36β or IL-36γ) is important to increase their
BIOLOG
ical activity. Recently it has been shown that IL-38 is N-terminally processed and secreted by apoptotic cells. Released processed IL-38 (20-152) binds to the receptor Interleukin-1 receptor accessory protein-like 1 (IL1RAPL1; TIGIRR-2) at the surface of macrophages. Processed IL-38-activated IL1RAPL1 reduces the production of IL-6 le
ADI
ng to inflammation attenuation.


Product References

Interleukin-38 is released from apoptotic cells to limit inflammatory macrophage responses: J. Mora, et al.; J. Mol. Cell Biol.
(Epub ahead of print)
(2016)