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商品編號


YIF-LF-P0221



品牌


Adipogen



公司


Adipogen



公司分類(lèi)


Proteins



Size

20 ?g

商品信息


More Information



Product Details



Synonyms

CDF; IL6; IL-6; BSF-2; IFNB2; IFN-β-2; Interleukin-6; Interferon β-2; Hybridoma Growth Factor; CTL Differentiation Factor; B-Cell Stimulatory Factor 2



Product Type

Protein



Properties



Source/Host

E. coli



Crossreactivity

Human



BIOLOG
ical Activity

The ED50 of IL-6 is typically 0.3-1 ng/ml. Measured in a cell proliferation assay using a murine myeloblastic cell line, B9.



Purity

≥95% (SDS-PAGE)



Concentration

1 mg/ml



Formulation

Liquid in PBS, 10% glycerol.



Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.



Declaration

Manufactured by AbFrontier



Shipping and Handling



Shipping

DRY ICE



Short Term Storage

-20°C



Long Term Storage

-80°C



Handling Advice

Avoid freeze/thaw cycles.



Documents



MSD
S

No



Product Specification Sheet



Datasheet


Download PDF





Interleukin-6 (IL-6) is a pleiotropic α-helical cytokine that plays important roles in a central player in the regulation of inflammation, haematopoiesis, immune response and host defense mechanisms. Human IL-6 molecular weight ranges between 21 and 28 kDa, depending on the state of glycosylation and phosphorylation. Mature human IL-6 is 183 amino acids and shares the homology between human and rat IL-6 is 41% at the amino acid level. IL-6 interacts with its receptor complex consisting of the membrane-bound IL-6 receptor (IL-6R) and the signal transducing protein gp130. IL-6R can exist as a soluble protein (sIL-6R), which binds the ligand IL-6. This soluble complex can bind to gp130 on cells that lack the membrane-bound IL-6R and initiate signaling. Two major signalling pathways are activated by IL-6: the JAK/STAT pathway and MAPK cascade.


Product References
1) Hoene M and Weigert C., (2008) Obes Rev (1):20-9. (General)
2) Hond DS et al., (2007) Cancer 110(9):1911-28. (General)
3) Knupfer H and Preiss R., (2008) Immunology and Cell
BIOLOG
y 86, 87-91. (General)