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商品編號


AG-40B-0136-C010



品牌


Adipogen



公司


Adipogen



公司分類(lèi)


Proteins



Size

10 ?g


商品信息


More Information



Product Details



Synonyms

Fibronectin Type III Domain-containing Protein 5 (cleaved); Fibronectin Type III Repeat-containing Protein 2 (cleaved); FNDC5 (cleaved)



Product Type

Protein



Properties



Source/Host

CHO cells



Sequence

Irisin (human, aa 32-143 /mouse, aa 29-140) is FLAG
?
-tagged at the N-terminus. Irisin has 100% identity between mouse, rat, monkey and human.



Crossreactivity

Human
Mouse



BIOLOG
ical Activity

Activates brown
ADI
pocyte
Marker
s Ucp1 and Cidec in murine subcutaneous
ADI
pocytes at 10ng/ml [Lit. 1].



MW

~26kDa



Purity

≥95% (SDS-PAGE)



Endotoxin Content

<0.01eu mu;g="" purified="" protein="" (lal="" test;="" lonza).="">0.01eu>



Concentration

0.1mg/ml after reconstitution.



Reconstitution

Reconstitute with 100μl sterile water.



Formulation

Lyophilized. Contains PBS.



Other Product Data

Uni-Prot link Q8NAU1: Irisin
FLAG is a registered trademark of
Sigma-Aldrich
Co.



Shipping and Handling



Shipping

BLUE ICE



Short Term Storage

+4°C



Long Term Storage

-20°C



Handling Advice

After reconstitution, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
PBS containing at least 0.1% BSA should be used for further dilutions.



Use/St
ABI
lity

Stable for at least 6 months after receipt when stored at -20°C.



Documents



MSD
S


Download PDF



Product Specification Sheet



Datasheet


Download PDF





Irisin is a recently described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin activates beige fat cells (beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone Irisin). Irisin is cleaved from the type I membrane protein FNDC5 and improves systemic metabolism by increasing energy expenditure.


Product References

Leptin admi
NIST
ration activates irisin-induced myogenesis via nitric oxide-dependent mechanisms, but reduces its effect on subcutaneous fat browning in mice: A. Rodriguez, et al.; Int. J. Obes.
39,
397 (2015)