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商品編號


CHI-HF-22008-C010



品牌


Adipogen



公司


Adipogen



公司分類(lèi)


Proteins



Size

10 ?g

商品信息


More Information



Product Details



Synonyms

Interleukin-8; CXCL8; C-X-C Motif Chemokine 8; Emoctakin; GCP-1; LAI; MDNCF; MONAP; NAP-1; NCF; TCF



Product Type

Protein



Properties



Source/Host

CHO cells



Sequence

The extracellular domain of human IL-8 (aa 23-99) is fused to the N-terminus of the Fc region of a mutant human IgG1.



Crossreactivity

Human



BIOLOG
ical Activity

Shows the
BIOLOG
ical function of the IL-8 moiety and exerts a prolonged circulating half-life caused by the modified Fc domain.



Purity

≥98% (SDS-PAGE)



Endotoxin Content

<0.06eu mu;g="" protein="" (lal="" test;="" lonza).="">0.06eu>



Reconstitution

Reconstitute 10?g vial in 100?l sterile water.
Reconstitute 50?g vial in 50?l sterile water.
Add 1X PBS to the desired protein concentration.



Formulation

Lyophilized from 0.2μm-filtered solution in PBS.



Other Product Data

Non-lytic: Acts as a long lasting fusion protein which only binds to the receptor. Mutations to the complement (C1q) and FcgR I binding sites of the IgGs Fc fragment render the fusion proteins incapable of antibody directed cytotoxicity (ADCC) and complement directed cytotoxicity (CDC).
NCBI reference NP_000575.1: IL-8 (human)



Declaration

Manufactured by Chimerigen.



Shipping and Handling



Shipping

BLUE ICE



Short Term Storage

+4°C



Long Term Storage

-20°C



Handling Advice

Avoid freeze/thaw cycles.



Use/St
ABI
lity

Stable for at least 1 year after receipt when stored at -20°C.
Working aliquots are stable for up to 3 months when stored at -20°C.



Documents



MSD
S

No



Product Specification Sheet



Datasheet


Download PDF





Interleukin-8 (IL-8) was originally discovered as a neutrophil chemotactic and activating factor and is a member of the α (CXC) subfamily of chemokines (including also platelet factor 4, GRO, IP-10, etc.). Many cell types, including monocyte/macrophages, T cells, neutrophils, fibroblasts, endothelial cells, keratinocytes, hepatocytes, chondrocytes and various tumor cell lines, produce IL-8 in response to a wide variety of proinflammatory stimuli such as exposure to IL-1, TNF, LPS and viruses. IL-8 has a wide range of other proinflammatory effects. It is a potent chemoattractant for neutrophils and causes degranulation of neutrophil specific granules and azurophilic granules. IL-8 induces expression of the cell adhesion molecules CD11/CD18 and enhances the adherence of neutrophils to endothelial cells and subendothelial matrix proteins. Besides neutrophils, IL-8 is also chemotactic for basophils, T cells and eosinophils. IL-8 has been reported to be a co-mitogen for keratinocytes and was also shown to be an autocrine growth factor for melanoma cells. IL-8 was also reported to be angiogenic both
in vivo
and
in vitro
.