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商品編號


AG-40B-0039-C050



品牌


Adipogen



公司


Adipogen



公司分類(lèi)


Proteins



Size

50 ?g


商品信息


More Information



Product Details



Synonyms

Lymphocyte Activation Gene-3; FDC Protein; CD223



Product Type

Protein



Properties



Source/Host

CHO cells



Sequence

The sequence coding for the 4 extracellular Ig-like domains of mouse LAG-3 (D1-D4) is fused to the Fc portion of mouse IgG2a (hinge-CH
2
-CH
3
).



Crossreactivity

Human
Mouse



Specificity

Binds to human and mouse MHC class II.



BIOLOG
ical Activity

Induces maturation of mouse dendritic cells
in vitro
. Induces CD4 and CD8 antigen-specific T cells responses when coinjected
s.c.
in mice, together with the antigen.



MW

~180kDa (SPS-PAGE, nonreducing), ~80kDa (SPS-PAGE, reducing)



Purity

≥95% (SDS-PAGE)



Endotoxin Content

<0.01eu mu;g="" purified="" protein="" (lal="" test;="" lonza).="">0.01eu>



Concentration

0.5 mg/ml



Formulation

Liquid. In PBS.



Other Product Data


Application: ?
Flow Cytometry: Detection of MHC class II molecules in combination with fluorescently labeled antibodies to IgG2a.
Uni-Prot link Q61790: LAG-3 (mouse)



Shipping and Handling



Shipping

DRY ICE



Short Term Storage

-20°C



Long Term Storage

-20°C



Handling Advice

After opening, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
PBS containing at least 0.1% BSA should be used for further dilutions.



Use/St
ABI
lity

Stable for at least 6 months after receipt when stored at -20°C.



Documents



MSD
S


Download PDF



Product Specification Sheet



Datasheet


Download PDF





Lymphocyte activation gene 3 (LAG-3; CD223) plays an important role in negatively regulating T cell proliferation, function and homeostasis. It is required for maximal natural and induced regulatory T cell (Treg) function. LAG-3 is closely related to the T cell co-receptor CD4 and binds to MHC class II molecules but with a significantly higher affinity than CD4.


Product References

LAG-3 enables DNA vaccination to persistently prevent mammary carcinogenesis in HER-2/neu transgenic BALB/c mice: P. Cappello, et al.; Cancer Res.
63,
2518 (2003)