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商品編號


AG-40A-0018-C050



品牌


Adipogen



公司


Adipogen



公司分類(lèi)


Proteins



Size

50 ?g


商品信息


More Information



Product Details



Synonyms

Pre-B Cell Colony Enhancing Factor 1; PBEF1; Nicotinamide Phosphoribosyltransferase



Product Type

Protein



Properties



Source/Host

E. coli



Sequence

Intracellular human Nampt (visfatin/PBEF) (aa 1-491) is fused at the C-terminus to a His-tag.



Crossreactivity

Human



BIOLOG
ical Activity

Shows
ADI
pogen
ic effects in stimulated differentiating 3T3-L1 cells.



MW

~52kDa (SDS-PAGE)



Purity

≥90% (SDS-PAGE)



Endotoxin Content

<1eu mu;g="" purified="" protein="" (lal="" test;="" lonza).="">1eu>



Reconstitution

Reconstitute in distilled water.



Formulation

Lyophilized. Salt-free.



Other Product Data

UniProt link P43490: Nicotinamide phosphoribosyltransferase (human)



Shipping and Handling



Shipping

BLUE ICE



Short Term Storage

+4°C



Long Term Storage

-20°C



Handling Advice

After reconstitution, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
For maximum product recovery after thawing, centrifuge the vial before opening the cap.



Use/St
ABI
lity

Working aliquots are stable for up to 3 months when stored at -20°C.



Documents



MSD
S


Download PDF



Product Specification Sheet



Datasheet


Download PDF





Nicotinamide phosphoribosyltransferase (Nampt; pre-B cell colony-enhancing factor; PBEF; Visfatin) is an 52kDa
ADI
pokine secreted by
ADI
pose tissue and involved in the biosynthesis of nicotinamide adenine dinucleotide (NAD+). Two forms of Nampt exist, an intracellular form (iNampt) and an extracellular form (eNampt). While the function of iNampt as an essential and rate-limiting NAD+ biosynthetic enzyme is well established, the physiological role of eNampt is still a matter of debate. Nampt has various functions, including the promotion of vascular smooth muscle cell maturation and inhibition of neutrophil apoptosis. It activates insulin receptor and has insulin-mimetic effects, lowering blood glucose and improving insulin sensitivity. The protein is highly expressed in visceral fat and serum levels of the protein correlate with obesity.


Product References

Visfatin is present in bovine mammary epithelial cells, lactating mammary gland and milk, and its expression is regulated by cAMP pathway: T. Yonezawa, et al.; FEBS Lett.
580,
6635 (2006)?

Molecular characteristics of serum visfatin and differential detection by immunoassays: A. K?rner, et al.; J. Clin. Endocrinol. Metab. 92, 4783 (2007) Lack of direct insulin-like action of visfatin/Nampt/PBEF1 in human
ADI
pocytes: E. Wanecq, et al.; J. Physiol. Biochem.
65,
351 (2009)

Expression and regulation of nampt in human islets: K. Kover, et al.; PLoS One
8,
e58767 (2013)