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商品編號


YIF-LF-P0301



品牌


Adipogen



公司


Adipogen



公司分類(lèi)


Proteins



Size

0.2 mg

商品信息


More Information



Product Details



Synonyms

NCK; NCK1; Nck-1; NCK Adaptor Protein 1; Cytoplasmic Protein NCK1; SH2/SH3 Adaptor Protein NCK-α



Product Type

Protein



Properties



Source/Host

E. coli



Crossreactivity

Human



Purity

≥95% (SDS-PAGE)



Formulation

Lyophilized from 50mM NaH2PO4, pH8.0, 300mM NaCl, 170mM imidazole.



Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.



Declaration

Manufactured by AbFrontier



Shipping and Handling



Shipping

BLUE ICE



Short Term Storage

+4°C



Long Term Storage

-20°C



Handling Advice

Avoid freeze/thaw cycles.



Use/St
ABI
lity

After reconstitution, store at -80°C.



Documents



MSD
S

No



Product Specification Sheet



Datasheet


Download PDF





NCK1 is one of the adaptor proteins which mediate specific protein-protein interactions in signaling processes. Adaptor proteins usually contain several domains like SH2 (Src homology 2) and SH3 which allow specific interactions with other specific proteins. NCK1 and NCK2 showing high sequence identity (68%) have three SH3 domains and a C-terminal SH2 domain. Both of them bind receptor tyrosine kinases such as PDGFR and other tyrosine phosphorylated proteins via their SH2 domains. Various molecules which interact with SH domains of Nck and regulate signaling process of actin
Cytoskeleton
reorganization have been identified. Ncks are thought to have important functions in the development of mesodermal structures during embryogenesis, linked to a role in cell movement and cytoskeletal reorganization. Nck also have a function in modulating mRNA translation at the level of initiation by interacting eukayotic initiation factor 2 (eIF2). Under the stressed conditions, protein synthesis is reduced by inhibiting the activity of eIF2 through the phosphorylation, transiently inhibiting recycling of eIF2 into its active form.


Product References
1) Latreille M and Larose L., (2006) J Biol Chem 281:26633-26644. (General)
2) Frese S et al., (2006) J Biol Chem 281:18236-18245. (General)
3) Bladt F et al., (2003) Mol Cell Biol 23:4586-4597. (General)