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商品編號


AG-40B-0040-3010



品牌


Adipogen



公司


Adipogen



公司分類(lèi)


Proteins



Size

3 x 10 ?g


商品信息


More Information



Product Details



Synonyms

NTN1



Product Type

Protein



Properties



Source/Host

HEK 293 cells



Sequence

Human netrin-1 (aa 25-604) is fused at the C-terminus to a FLAG
?
-tag.



Crossreactivity

Human
Mouse
Rat



Specificity

Binds to human, mouse and rat UNC5B.



BIOLOG
ical Activity

Induces pluripotent stem cell (iPS) formation and improves reprogramming efficiency of human and mouse somatic cells by inhibiting apoptosis mediated by the receptors DCC or UNC5B (at 150ng /ml). Induces axon outgrowth.



MW

~80kDa (SDS-PAGE)



Purity

≥95% (SDS-PAGE)



Endotoxin Content

<0.01eu mu;g="" purified="" protein="" (lal="" test;="" lonza).="">0.01eu>



Concentration

10?g vial: 0.1mg/ml after reconstitution.
100?g vial: 1mg/ml after reconstitution.



Reconstitution

Reconstitute with 100μl sterile distilled water.



Formulation

Lyophilized. Contains PBS plus protein st
ABI
lizer. No BSA included. The protein st
ABI
lizer shows no interference with protein activity.



Other Product Data

UniProt link O95631:
Netrin-1 (human)



Shipping and Handling



Shipping

BLUE ICE



Short Term Storage

+4°C



Long Term Storage

-20°C



Handling Advice

After reconstitution, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
PBS containing at least 0.1% BSA should be used for further dilutions.



Use/St
ABI
lity

Stable for at least 6 months after receipt when stored at -20°C.



Documents



MSD
S


Download PDF



Product Specification Sheet



Datasheet


Download PDF





Netrin-1 controls guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Netrin-1 is also Involved in tum
Origen
esis by regulating apoptosis. Netrin-1 promotes atherosclerosis by retaining macrophages in the artery wall. Netrin-1 also governs induced pluripotent stem cell (iPS) formation and improves reprogramming efficiency of human and mouse somatic cells by limiting apoptosis mediated by Netrin-1 receptors DCC or UNC5b.


Product References

Netrin-1 regulates somatic cell reprogramming and pluripotency maintenance: D. Ozmadenci, et al.; Nat. Commun.
6,
ID7398 (2015)

Targeting netrin‐1/DCC interaction in diffuse large B‐cell and mantle cell lymphomas: L. Broutier, et al.; EMBO Mol. Med.
8,
96 (2016)

Inhibition of DNA methylation promotes breast tumor sensitivity to netrin‐1 interference: M. Grandin, et al.; EMBO Mol. Med.
8,
863 (2016)