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商品編號


AG-40A-0153T-3010



品牌


Adipogen



公司


Adipogen



公司分類(lèi)


Proteins



Size

3 x 10 ?g


商品信息


More Information



Product Details



Synonyms

Nicotinamide Mononucleotide Adenylyltransferase 2; NMN Adenylyltransferase 2; NaMN Adenylyltransferase 2



Product Type

Protein



Properties



Source/Host

E. coli



Sequence

Human NMNA2 (aa 2-307) is fused at the N-terminus to a His-tag.



Crossreactivity

Human



MW

~35kDa (SDS-PAGE)



Purity

≥90% (SDS-PAGE)



Concentration

0.1mg/ml after reconstitution.



Reconstitution

Reconstitute with 100μl sterile water.



Formulation

Lyophilized in 55mM TRIS-Cl, pH 8.2, containing 150mM NaCl plus 0.025% CHAPS.



Other Product Data

UniProt link Q9BZQ4: NMNAT2 (human)



Shipping and Handling



Shipping

BLUE ICE



Short Term Storage

+4°C



Long Term Storage

-20°C



Handling Advice

After reconstitution, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
PBS containing at least 0.1% BSA should be used for further dilutions.



Use/St
ABI
lity

Stable for at least 6 months after receipt when stored at -20°C.



Documents



MSD
S


Download PDF



Product Specification Sheet



Datasheet


Download PDF





Nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2) catalyzes the formation of NAD
+
from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form nicotinic acid mononucleotide (NaMN) as a substrate but with lower efficiency. NMNAT2 also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD
+
. It is highly expressed in brain, in particular in cerebrum, cerebellum, occipital lobe, frontal lobe, temporal lobe and putamen. NMNAT2 is also found in the heart, skeletal muscle, pancreas and islets of Langerhans. NMNAT2 is essential for axon growth and survival. Its loss from injured axons may activate Wallerian degeneration (axon degeneration induced by nerve injury), whereas NMNAT overexpression rescues axons from degeneration.