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商品編號


AG-40T-0311-C050



品牌


Adipogen



公司


Adipogen



公司分類(lèi)


Proteins



Size

50 ?g

商品信息


More Information



Product Details



Synonyms

Ubiquitin Thioesterase Otulin; Deubiquitinating Enzyme Otulin; OTU Domain-containing Deubiquitinase with Linear Linkage Specificity; Ubiquitin Thioesterase Gumby



Product Type

Protein



Properties



Source/Host

E. coli



Sequence

Human otulin (Accession Nr. Q96BN8).



Crossreactivity

Human



MW

41kDa



Purity

≥95% (SDS-PAGE)



Formulation

Liquid. In 50mM HEPES pH 8.0, 100mM NaCl, 2mM DTT, 10% glycerol.



Other Product Data


Use:
Linear ubiquitin-specific deconjugating enzyme. Reaction conditions will need to be optimized for each specific application. We recommend an initial protein concentration of 0.05-1?M.



Declaration

Manufactured by Boston Biochem



Shipping and Handling



Shipping

DRY ICE



Short Term Storage

-20°C



Long Term Storage

-80°C



Handling Advice

Aliquot to avoid freeze/thaw cycles.



Use/St
ABI
lity

Stable for at least 1 year after receipt when stored at -80°C.



Documents



MSD
S

No



Product Specification Sheet



Datasheet


Download PDF





Otulin (FAM105B) is a C65 type peptidase and a member of the ovarian tumor (OTU) protein super-family. Otulin has exquisite specificity for linear (methionine-1-linked) ubiquitin linkages and has been shown to play a role in the regulation of NF-κB mediated signaling. It is a negative regulator of Inflammation and autoimmunity.


Product References

OTULIN restricts Met1-linked ubiquitination to control innate immune signaling: B.K. Fiil, et al.; Mol. Cell
50,
818 (2013)