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商品編號


AG-40T-0023-C002



品牌


Adipogen



公司


Adipogen



公司分類(lèi)


Proteins



Size

2 ?g


商品信息


More Information



Product Details



Synonyms

Histone Acetyltransferase p300; p300 HAT; E1A-associated Protein p300



Product Type

Protein



Properties



Source/Host

Sf21 cells



Sequence

Human p300 is fused to a His-tag.



Crossreactivity

Human



BIOLOG
ical Activity

100 ng required for acetylation assay.



Purity

≥95% (SDS-PAGE)



Concentration

Lot dependent (0.2-1.5mg/ml)



Formulation

Liquid. In 50mM TRIS-HCl, pH 7.5, containing 100mM sodium chloride, 0.2% NP-40, 50mM imidazole and 10% glycerol.



Other Product Data

UniProt ID Q09472:?p300 (human)



Shipping and Handling



Shipping

DRY ICE



Short Term Storage

-20°C



Long Term Storage

-80°C



Handling Advice

After opening, prepare aliquots and store at -80°C.
Avoid freeze/thaw cycles.



Use/St
ABI
lity

Stable for at least 6 months after receipt when stored at -80°C.



Documents



MSD
S


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Product Specification Sheet



Datasheet


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p300 functions as histone acetyltransferase and regulates transcription via chromatin remodeling. It acetylates all four core histones in nucleosomes, while the histone acetylation gives an epigenetic tag for transcriptional activation. p300 mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. It functions as a acetyltransferase for nonhistone targets. It acetylates 'Lys-131' of ALX1 and acts as its coactivator in the presence of CREBBP. p300 acetylates sirtuin 2 (SIRT2) and is proposed to indirectly increase the transcriptional activity of TP53 through acetylation and subsequent attenuation of SIRT2 deacetylase function. It acetylates HDAC1 le
ADI
ng to its inactivation and modulation of transcription. It promotes cardiac myocyte enlargement and binds to and may be involved in the transforming capacity of the adenovirus E1A protein. In case of HIV-1 infection, it is recruited by the viral protein Tat. p300 regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. It acetylates FOXO1 and enhances its transcriptional activity.


Product References

Functional relevance of novel p300-mediated lysine 314 and 315 acetylation of RelA/p65: C. Buerki, et al.; Nucleic Acids Res.
36,
1665 (2008)