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商品編號


AG-40B-0014-3050



品牌


Adipogen



公司


Adipogen



公司分類(lèi)


Proteins



Size

3 x 50 ?g


商品信息


More Information



Product Details



Synonyms

TNFRSF 4; Tumor Necrosis Factor Receptor Superfamily Member 4; CD134



Product Type

Protein



Properties



Source/Host

HEK 293 cells



Sequence

Human OX40 (aa 29-214) is fused at the C-terminus to the Fc portion of human IgG1.



Crossreactivity

Human
Mouse



Specificity

Binds to human and mouse OX40L.



BIOLOG
ical Activity

Blocks T cell proliferation induced by CD134L.



MW

~70kDa (SDS-PAGE)



Purity

≥95% (SDS-PAGE)



Endotoxin Content

<0.01eu mu;g="" purified="" protein="" (lal="" test;="" lonza).="">0.01eu>



Concentration

1mg/ml after reconstitution.



Reconstitution

Reconstitute with 50μl sterile water.



Formulation

Lyophilized. Contains PBS.



Other Product Data

UniProt link P43489: CD134 (human) (precursor)



Shipping and Handling



Shipping

BLUE ICE



Short Term Storage

+4°C



Long Term Storage

-20°C



Handling Advice

After reconstitution, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
PBS containing at least 0.1% BSA should be used for further dilutions.



Use/St
ABI
lity

Stable for at least 6 months after receipt when stored at -20°C.



Documents



MSD
S


Download PDF



Product Specification Sheet



Datasheet


Download PDF





OX40 binds to receptors on T-cells, preventing them from dying and subsequently increasing cytokine production. OX40 has a critical role in the maintenance of an immune response. OX40:Fc was shown to prevent OX40 from reaching the T-cell receptors, thus reducing the T-cell response. Experiments in mice have demonstrated that OX40:Fc can reduce the symptoms associated with the cytokine storm (an immune overreaction) while allowing the immune system to fight off the virus successfully.