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商品編號


SBB-US0012-C020



品牌


Adipogen



公司


Adipogen



公司分類(lèi)


Proteins



Size

20 ?g

商品信息


More Information



Product Details



Synonyms

Cellular Tumor Antigen p53; Tumor Suppressor p53; TP53



Product Type

Protein



Properties



Source/Host

E. coli



Sequence

Human p53 (aa 2-393) (Accession Nr. P04637) fused to a N-terminal His-tag, ubiquitinated by MDM2, and subsequently purified from conjugation-reaction proteins/enriched post-conjugation.



Crossreactivity

Human



Application

Typical working concentrations range is 0.5-2?M.



MW

>40kDa. Western blot analysis shows multiple states of poly-ubiquitination, and deconjugation with
USP
7 shows purified ubiquitinated p53 can function as a native substrate.



Purity

≥95% (SDS-PAGE)



Concentration

Lot dependent.



Accession Number

P04637



Formulation

Liquid. In 50mM HEPES pH 7.5, 500 mM sodium chloride, 10% glycerol, 2mM TCEP.



Other Product Data

Click here for a Typical Lot-specific Product Datasheet from the Original Manufacturer
Our product description may differ slightly from the original manufacturers product datasheet.



Declaration

Manufactured by South Bay Bio.



Shipping and Handling



Shipping

DRY ICE



Short Term Storage

-80°C



Long Term Storage

-80°C



Handling Advice

Aliquot to avoid freeze/thaw cycles.



Use/St
ABI
lity

Stable for at least 1 year after receipt when stored at -80°C.



Documents



MSD
S

No



Product Specification Sheet



Datasheet


Download PDF





p53 acts as a tumor suppressor in many tumor types, induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. E3 ligase MDM2 mediated ubiquitin conjugation of p53 and subsequent p53 down-regulation via proteasomal degradation interrupts this crucial role, contributing to tumorogenesis (and cancer).