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商品編號


AG-40T-0015-C010



品牌


Adipogen



公司


Adipogen



公司分類(lèi)


Proteins



Size

10 ?g


商品信息


More Information



Product Details



Synonyms

Poly(ADP-ribose) Polymerase 1; ADP-ribosyltransferase Diphtheria Toxin-like 1; NAD(+) ADP-ribosyltransferase 1



Product Type

Protein



Properties



Source/Host

Sf21 cells



Sequence

Human full-length inactive mutant E998K of PARP-1 is fused to a HA-tag and a His-tag.



Crossreactivity

Human



Application

Control



BIOLOG
ical Activity

0.5% of wild type PARP-1.



Purity

≥95% (SDS-PAGE)



Concentration

Lot dependent (0.2-0.5mg/ml)



Formulation

Liquid. In 50mM TRIS-HCl, pH 7.5, containing 100mM sodium chloride and 50mM imidazole, 0.2% NP-40 and 10% glycerol.



Other Product Data

UniProt ID P09874:?PARP-1 (human)



Shipping and Handling



Shipping

DRY ICE



Short Term Storage

-20°C



Long Term Storage

-80°C



Handling Advice

After opening, prepare aliquots and store at -80°C.
Avoid freeze/thaw cycles.



Use/St
ABI
lity

Stable for at least 6 months after receipt when stored at -80°C.



Documents



MSD
S


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Product Specification Sheet



Datasheet


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PARP-1 (ARTD1) is involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway le
ADI
ng to the reparation of DNA strand breaks. PARP-1 positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. It forms a complex with EEF1A1 and TXK that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-γ to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. PARP-1 (E998K mutant) is an inactive form of PARP-1 which can be used as a control compound.


Product References

The enzymatic and DNA binding activity of PARP-1 are not required for NF-kappa B coactivator function: P.O. Hassa, et al.; J. Biol. Chem.
276,
45588 (2001)