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商品編號


AG-40B-0077-3010



品牌


Adipogen



公司


Adipogen



公司分類(lèi)


Proteins



Size

3 x 10 ?g


商品信息


More Information



Product Details



Synonyms

Pigment Epithelium-derived Factor; Cell Proliferation-inducing Gene 35 Protein; EPC-1; Serpin F1



Product Type

Protein



Properties



Source/Host

CHO cells



Sequence

Human PEDF (aa 20-418) is fused at the C-terminus of to a FLAG
?
-tag.



Crossreactivity

Human



MW

~47kDa (SDS-PAGE)



Purity

≥95% (SDS-PAGE)



Endotoxin Content

<0.1eu mu;g="" purified="" protein="" (lal="" test;="" lonza).="">0.1eu>



Concentration

0.1mg/ml after reconstitution.



Reconstitution

Reconstitute with 100μl sterile distilled water.



Formulation

Lyophilized. Contains PBS.



Other Product Data

UniProt link P36955: PEDF (human)



Shipping and Handling



Shipping

BLUE ICE



Short Term Storage

+4°C



Long Term Storage

-20°C



Handling Advice

After reconstitution, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
PBS containing at least 0.1% BSA should be used for further dilutions.



Use/St
ABI
lity

Stable for at least 6 months after receipt when stored at -20°C.



Documents



MSD
S


Download PDF



Product Specification Sheet



Datasheet


Download PDF





Pigment epithelium-derived factor (PEDF) is a 47 kDa secreted glycoprotein that belongs to the non-inhibitory serpin family group. PEDF is widely expressed in adult and foetal tissues, including brain, spinal cord, plasma, bone, prostate, pancreas, heart and lung. PEDF acts as an angiogenesis inhibitor with neurotrophic, immunomodulation and antitumor properties. It functions as anti-angiogenic agent by counterbalancing the proangiogenic effect of VEGF. PEDF is one of the most abundant proteins released by
ADI
pocytes and induces insulin resistance in
ADI
pocytes and human skeletal muscle cells. Recently, it has been reported that PEDF is sufficient to maintain the self-renewal of pluripotent human embryonic stem cells.