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商品編號


GWB-521226



品牌


GenWay



公司


GenWay



公司分類(lèi)


ELISAs



Size

1x96 Assays

商品信息

Description:
1. INTRODUCTION
Reumathoid arthritis (RA) is one of the most common autoimmune diseases (1-2% European population). The most significant clinical symptom is an inflammation of the synovial membranes which causes a painful swelling of the articulations and the ankylosis. In order to correctly diagnose RA it is necessary to exclude other forms of arthritis: in such a diagnostic process, the laboratory plays an important role in the determination of Rheumatoid Factor (RF) antibodies of class IgM, detectable in 60-80% of the patients with RA. The RF antibodies are sensitive but not very specific
Marker
s; on the contrary, anti-CCPs are characterized by a specificity of over 90% in patients affected by RA ,and are detectable in a very early asymptomatic stage in the approximately 70% of RA patients whereas only 2% of the control subjects resulted positive. Therefore, the presence of Anti-CCP antibodies can be used in the diagnosis of RA, particularly in the case of erosive arthritis, in childhood in the case of juvenile RA. The test also appears, to be useful in differentiating the collagen pathologies with concomitant arthritis from the RA. The Anti-CCP antibodies test has an important prognostic value in the monitoring of articular r
ADI
ologically detectable damage. The kit’s quantitative determination is useful in the control and verification of the effects of pharmacological therapy. The Anti-CCP antibody test, together with the determination of RF, increases the ratio of sensitivity / specificity. 20% of the RAs are RF-negative and 15/20% of the RAs are positive only to RF. The simultaneous positive result of a sample to RF and CCP has a positive predictive value of about 100%. The levels of anti-CCP antibodies are not necessarily correlated to the evolutionary stage of the illness. The advantage of the anti-CCP antibodies is that they are detectable in the patient sera up to 10 years prior to the appearance of symptoms. In addition, in cases of early arthritis a positive test result, according to some studies is related to the development of bone erosive lesions of the articulations.

2. INTENDED USE
Anti-CCP kit is an immunoenzymatic test (
ELISA
), intended for the quantitative determination of IgG class antibodies directedagainst cyclic citrullinated peptides, present in human serum or plasma.Anti CCP kit is intended for laboratory use only.

3. PRINCIPLE OF THE ASSAY

The anti-CCP IgG test is based on binding of antibodies present in the sample to cyclical citrullinated peptides coated into the microplates.Any present antibodies in calibrators, controls or prediluted patient samples bind to the inner surface of the wells. After a 60 minutesincubation the microplate is washed with wash buffer for removing non-reactive Serum or Plasma components.An anti-human-IgG horser
ADI
sh peroxidase conjugate solution recognize IgG class antibodies bound to the immobilized antigens.After a 30 minutes incubation any excess enzyme conjugate, which is not specifically bound is washed away with wash buffer.A chromogenic substrate solution containing TMB is dispensed into the wells. After 15 minutes of incubation the color developmentis stopped by adding the stop solution. The solution color change into yellow. The amount of color is directly proportional to theconcentration of IgG antibodies present in the original sample.
Additional Information:




Name

Anti-CCP



Related Product Names

Anti-Cyclic Citrullinated Protein antibodies (anti-CCP)
ELISA
Kit, Anti-Cyclic Citrullinated Protein antibodies
ELISA
, Anti CCP
ELISA
, Anti-Citrullinated Protein Antibodies (ACPA)
ELISA
Kit, Anti-Citrullinated Protein Antibodies
ELISA
, ACPA
ELISA
, Rheumat



Molecular Weight

0.5



Concentration

Lot Specific



Applications

Enzyme immunoassay for the quantitative determination of anti CCP in human serum or plasma



Reactivity

Human



Intended Use

Research Use Only