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商品編號


AG-40T-0541-C100



品牌


Adipogen



公司


Adipogen



公司分類(lèi)


Proteins



Size

100 ?g

商品信息


More Information



Product Details



Synonyms

Ubiquitin C-terminal Hydrolase 28; Deubiquitinating Enzyme 28; Ubiquitin Thioesterase 28; Ubiquitin-specific-processing Protease 28



Product Type

Protein



Properties



Source/Host

Sf21 cells



Sequence

Human
USP
28 (Accession Nr. Q96RU2) fused to a C-terminal His-tag.



Crossreactivity

Human



Formulation

Liquid. In HEPES, NaCl and TCEP.



Other Product Data


Use:
Ubiquitin-specific deconjugating enzyme. Reaction conditions will need to be optimized for each specific application. We recommend an initial protein concentration of 10-500nM.



Declaration

Manufactured by Boston Biochem



Shipping and Handling



Shipping

DRY ICE



Short Term Storage

-20°C



Long Term Storage

-80°C



Handling Advice

Aliquot to avoid freeze/thaw cycles.



Use/St
ABI
lity

Stable for at least 1 year after receipt when stored at -80°C.



Documents



MSD
S

No



Product Specification Sheet



Datasheet


Download PDF





USP
28 is a deubiquitinating enzyme of the C19 peptidase family that regulates MYC st
ABI
lity and DNA damage response checkpoints.
USP
28 regulates DNA repair by deubiquitinating and thereby st
ABI
lizing CLSPN, a protein that is ubiquitinated by the APC/C E3 ubiquitin ligase in a cell-cycle dependent manner.
USP
28 interacts with isoform 1 of FBXW7 in the nucleoplasm, and regulates MYC degradation by counteracting its ubiquitination. A potential role in HIF-1α-dependent processes such as angiogenesis and metastasis has been described for this deubiquitinase.
USP
28 has been demonstrated to cleave K6, K11, K48, and K63-linked poly-ubiquitin chains.