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商品編號


AG-40T-0049-C005



品牌


Adipogen



公司


Adipogen



公司分類(lèi)


Proteins



Size

5 ?g


商品信息


More Information



Product Details



Synonyms

Vascular Endothelial Growth Factor Receptor 1; FLT-1; Fms-like Tyrosine Kinase 1



Product Type

Protein



Properties



Source/Host

Sf9 cells



Sequence

Human sVEGFR-1 (663aa).



Crossreactivity

Human



BIOLOG
ical Activity

The activity of sVEGFR-1 was determined by its
ABI
lity to inhibit the VEGF-A-induced proliferation of HUVECs.



MW

~96kDa (monomer)



Purity

≥95% (SDS-PAGE)



Reconstitution

Soluble in water and most aqueous buffers. Reconstitute with PBS to a concentration not lower than 100ng/ml.



Formulation

Lyophilized.



Other Product Data

UniProt link P17948-2: sVEGFR-1 (human)



Shipping and Handling



Shipping

BLUE ICE



Short Term Storage

+4°C



Long Term Storage

-20°C



Handling Advice

Avoid freeze/thaw cycles.



Use/St
ABI
lity

After reconstitution, store at -80°C.
Stable for at least 6 months after receipt when stored at -20°C.



Documents



MSD
S


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Product Specification Sheet



Datasheet


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Recombinant human soluble vascular endothelial growth factor receptor-1 (sVEGFR-1) is the naturally occurring form and is a glycosylated monomeric protein. The
BIOLOG
ical function of sVEGFR-1 seems to be an endogenous regulator of angiogenesis, binding VEGF with the same affinity as the full-length receptor. VEGFR-1 is a tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis and cancer cell invasion. It may play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. It can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts
(in vitro)
. It has a very high affinity for VEGFA and relatively low protein kinase activity. It may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Modulates KDR signaling by forming heterodimers with KDR. Ligand binding leads to the activation of several signaling cascades. Activation of phospholipase C-γ (PLCG) leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, le
ADI
ng to activation of phosphatidylinositol kinase and the downstream signaling pathway. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Phosphorylates SRC and YES1 and may also phosphorylate CBL.


Product References

Soluble VEGFR-1 secreted by endothelial cells and monocytes is present in human serum and plasma from healthy donors: B. Barleon, et al.; Angiogenesis
4
, 143 (2001)

Poor responder-high responder: the importance of soluble vascular endothelial growth factor receptor 1 in ovarian stimulation protocols: J. Neulen, et al.; Human Reprod.
16
, 621 (2001)

Activation of Vascular Endothelial Growth FactorReceptor-1 Sustains Angiogenesis and Bcl-2 ExpressionVia the Phosphatidylinositol 3-Kinase Pathway in Endothelial Cells: J. Cai, et al.; Diabetes
52
, 2959 (2003)

Elevated Placental Soluble Vascular Endothelial Growth Factor Receptor-1 Inhibits Angiogenesis in Preeclampsia: S. Ahmad & A. Ahmed; Circ. Res.
95
, 884 (2004)

Autocrine activity of soluble Flt-1 controls endothelial cell function and angiogenesis: S. Ahmad, et al.; Vasc. Cell
3
, 15 (2011)

The role of heterodimerization between VEGFR-1 and VEGFR-2 in the regulation of endothelial cell homeostasis: MJ. Cudmore, et al.; Nat. Commun.
3
, 972 (2012)

Altered redox state modulates endothelial KCa2.3 and KCa3.1 levels in normal pregnancy and preeclampsia: S. Choi, et al.; Antioxid. Redox. Signal, ahead of print (2018)