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商品編號


K0105B



品牌


Accelagen



公司


Accelagen



公司分類(lèi)


Kinases



Concentration

1 mg/ml


Size

Bulk

商品信息


Description:
Human PAK2 kinase (UniProt: Q13177; NCBI: NM_002577) belongs to a family of p21-activated kinases. These serine/threonine kinases are regulated by the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of
BIOLOG
ical activities. PAK2 is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell.
PAK2KD is a recombinant wild type human PAK2 kinase domain (amino acids 227–524 of full-length human PAK2) expressed in E. coli and purified to near homogeneity with high specific activity.

Molecular Mass and Phosphorylation:
The calculated mass is 33,510. PAK2KD is fully phosphorylated at T402 and partially phosphorylated at additional sites with measured mass of 33,593 (1P), 33,673 (2P), 33,753 (3P), and 33,834 (4P).

St
ABI
lity and Storage:
Stable at -70
o
C for 12 months from date of receipt. Protein should be thawed on ice. Protein can be flash-frozen in liquid nitrogen and stored at -70
o
C.

Applications:
Enzymatic studies, inhibitor screen, and selectivity profiling
High concentration available for crystallization