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商品編號


K0106M



品牌


Accelagen



公司


Accelagen



公司分類(lèi)


Kinases



Concentration

1 mg/ml


Size

100 ?g

商品信息


Description:
Human PAK3 kinase (UniProt: O75914; NCBI: NM_001128166) belongs to a family of p21-activated kinases. These serine/threonine kinases serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of
BIOLOG
ical activities. Overexpression of PAK3 has been detected in certain types of cancer. Mutations of PAK3 have been associated with learning dis
ABI
lity and X-linked mental retardation. PAK3KD is a recombinant wild type human PAK3 kinase domain (amino acids 246-544 of full-length human PAK3) expressed in E. coli and purified to near homogeneity.

Molecular Mass and Phosphorylation:
The calculated mass is 33,758. PAK3KD is phosphorylated on T421 and partially phosphorylated at additional sites with mass measured at 33,835 (1P), 33,915 (2P), 33,995 (3P).

St
ABI
lity and Storage:
Stable at -70
o
C for 12 months from date of receipt. Protein should be thawed on ice. Protein can be flash-frozen in liquid nitrogen and stored at -70
o
C.

Applications:
Enzymatic studies, inhibitor screen, and selectivity profiling
High concentration available for crystallization