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商品編號


2936/10



品牌


Tocris



公司


Bio-Techne Corporation



公司分類(lèi)


Ligases



Size

10 mg

商品信息

Description:
MDM2 antago
NIST
. Disrupts MDM2-p53 interaction

Chemical Name:
2-Methyl-7-[Phenyl(phenylamino)methyl]-8-quinolinol

Purity:
≥97% (HPLC)


BIOLOG
ical Activity Technical Data Solubility Calculators Datasheets References


BIOLOG
ical Activity

Potent MDM2 inhibitor (K
i
= 120 nM) which disrupts MDM2-p53 interaction and activates p53 function. Induces p21, p53 and MDM2 accumulation in human colon cancer cells
in vitro
.



Technical Data



M. Wt

340.42



Formula

C
23
H
20
N
2
O



Storage

Store at +4°C



Purity

≥97% (HPLC)



CAS Number

6964-62-1



PubChem ID

248986



InChI Key

WEENRMPCSWFMTE-UHFFFAOYSA-N



Smiles

CC2=NC1=C(O)C(C(NC4=CC=CC=C4)C3=CC=CC=C3)=CC=C1C=C2



The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All
Tocris
products are intended for laboratory research use only.



Solubility Data




Solvent

Max Conc. mg/mL

Max Conc. mM



Solubility



DMSO

34.04

100





Preparing Stock Solutions

The following data is based on the
product
molecular weight
340.42
. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.



Concentration / Solvent Volume / Mass

1 mg

5 mg

10 mg



1 mM

2.94 mL

14.69 mL

29.38 mL



5 mM

0.59 mL

2.94 mL

5.88 mL



10 mM

0.29 mL

1.47 mL

2.94 mL



50 mM

0.06 mL

0.29 mL

0.59 mL






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Product Datasheets


Certificate of Analysis / Product Datasheet


Safety Datasheet

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References

References are publications that support the products'
BIOLOG
ical activity.


Lu

et al
(2006) Discovery of a nanomolar inhibitor of the human murine double minute 2 (MDM2)-p53 interaction through an integrated, virtual database screening strategy. J.Med.Chem.
49
3759 PMID: 16789731


Shangary and Shaomeng
(2009) Small-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: a novel approach for cancer therapy. Ann.Rev.Pharmacol.Toxicol.
49
223 PMID:




Keywords: NSC 66811, supplier, MDM2, antago
NIST
s, Disrupts, MDM2-p53, interaction, Transcription, Factors, NSC66811, p53, Ubiquitin, E3, Ligases, Ubiquitin, E3, Ligases,
Tocris
Bioscience