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商品編號


3255/50



品牌


Tocris



公司


Bio-Techne Corporation



公司分類(lèi)


Polymerases



Size

50 mg

商品信息

Description:
Potent PARP inhibitor

Chemical Name:

N
-(5,6-Dihydro-6-oxo-2-phenanthridinyl)-2-acetamide hydrochloride

Purity:
≥98% (HPLC)


BIOLOG
ical Activity Technical Data Solubility Calculators Datasheets References


BIOLOG
ical Activity

Potent inhibitor of poly(ADP-ribose) polymerase (PARP) (EC
50
= 20 nM). ~1000-fold more potent than 3-Aminobenzamide (Cat. No. 0788). Protects primary neuronal cells from oxygen-glucose deprivation
in vitro
and reduces infarct size following focal cerebral ischemia
in vivo
. Displays protective effects against cisplatin-induced kidney injury. Also displays activity at Pim-1 and Pim-2 kinases at higher concentrations (IC
50
values are 3.7 and 16
μ
M respectively).



Compound Libraries

PJ 34 hydrochloride is also offered as part of the
Tocris
creen Plus and
Tocris
creen Epigenetics Toolbox. Find out more about compound libraries available from
Tocris
.



Technical Data



M. Wt

331.8



Formula

C
17
H
17
N
3
O
2
.HCl



Storage

Desiccate at RT



Purity

≥98% (HPLC)



CAS Number

344458-15-7



PubChem ID

16760621



InChI Key

RURAZZMDMNRXMI-UHFFFAOYSA-N



Smiles

Cl.CN(C)CC(=O)NC1=CC2=C(NC(=O)C3=CC=CC=C23)C=C1



The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All
Tocris
products are intended for laboratory research use only.



Solubility Data




Solvent

Max Conc. mg/mL

Max Conc. mM



Solubility



DMSO

33.18

100



water

33.18

100





Preparing Stock Solutions

The following data is based on the
product
molecular weight
331.8
. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.



Concentration / Solvent Volume / Mass

1 mg

5 mg

10 mg



1 mM

3.01 mL

15.07 mL

30.14 mL



5 mM

0.6 mL

3.01 mL

6.03 mL



10 mM

0.3 mL

1.51 mL

3.01 mL



50 mM

0.06 mL

0.3 mL

0.6 mL






Molarity Calculator






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Dilution Calculator






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Product Datasheets


Certificate of Analysis / Product Datasheet


Safety Datasheet

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References

References are publications that support the products'
BIOLOG
ical activity.


A
BD
elkarim

et al
(2001) Protective effects of PJ34, a novel, potent inhibitor of poly(ADP-ribose) polymerase (PARP) in
in vitro
and
in vivo
models of stroke. Int.J.Mol.Med.
7
255 PMID: 11179503


Gambi

et al
(2008) Poly(ADPR)polymerase inhibition and apoptosis induction in cDDP-treated human carcinoma cell lines. Biochem.Pharmacol.
75
2356 PMID: 18468580


Kim

et al
(2012) Poly(ADP-ribose) polymerase 1 activation is required for cisplatin nephrotoxicity. Kidney Int.
82
193 PMID: 22437413


Antolin

et al
(2012) Identification of Pim kinases as novel targets for PJ34 with confounding effects in PARP
BIOLOG
y. ACS Chem.Biol.
7
1962 PMID: 23025350




Keywords: PJ 34 hydrochloride, supplier, Potent, PARP, inhibitors, inhibits, PolyADP-ribose, Polymerases, PJ34, hydrochloride, Poly(ADP-ribose), Polymerase, Poly(ADP-ribose), Polymerase,
Tocris
Bioscience