Tocris/PYR 41/2978/50/50 mg
克隆和表達
商品編號
2978/50
品牌
Tocris
公司
Bio-Techne Corporation
公司分類(lèi)
Ligases
Size
50 mg
商品信息
Description:
Ubiquitin-activating enzyme (E1) inhibitor
Chemical Name:
4-[4-[(5-Nitro-2-furanyl)methylene]-3,5-dioxo-1-pyrazolidinyl]benzoic acid ethyl ester
Purity:
≥98% (HPLC)
BIOLOG
ical Activity
Technical Data
Solubility
Calculators
Datasheets
References
BIOLOG
ical Activity
Cell-permeable, irrevers
IBL
e ubiquitin-activating enzyme (E1) inhibitor (IC
50
< 10
μ
M). Blocks ubiquitination and prevents ubiquitin-mediated proteasomal degradation. Inhibits NF-
κ
B activation, blocks degradation of p53, increases p21 levels and induces apoptosis
in vitro
. Also causes an increase in sumoylation of proteins.
Technical Data
M. Wt
371.3
Formula
C
17
H
13
N
3
O
7
Storage
Store at -20°C
Purity
≥98% (HPLC)
CAS Number
418805-02-4
PubChem ID
2856906
InChI Key
ARGIPZKQJGFSGQ-UHFFFAOYSA-N
Smiles
CCOC(=O)C1=CC=C(C=C1)N1NC(=O)C(=CC2=CC=C(O2)[N+]([O-])=O)C1=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All
Tocris
products are intended for laboratory research use only.
Solubility Data
Solvent
Max Conc. mg/mL
Max Conc. mM
Solubility
DMSO
37.13
100
Preparing Stock Solutions
The following data is based on the
product
molecular weight
371.3
. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass
1 mg
5 mg
10 mg
1 mM
2.69 mL
13.47 mL
26.93 mL
5 mM
0.54 mL
2.69 mL
5.39 mL
10 mM
0.27 mL
1.35 mL
2.69 mL
50 mM
0.05 mL
0.27 mL
0.54 mL
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Product Datasheets
Certificate of Analysis / Product Datasheet
Safety Datasheet
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References
References are publications that support the products'
BIOLOG
ical activity.
Yang
et al
(2007) Inhibitors of ubiquitin-activating enzyme (E1), a new class of potential cancer therapeutics. Cancer Res.
67
9472 PMID: 17909057
Mi
et al
(2009) Cancer preventative isothiocyanates induce selective degradation of cellular α- and β-tubulins by proteasomes. J.Biol.Chem.
284
17039 PMID: 19339240
Brahemi
et al
(2010) Homology modelling of human E1 ubiquitin activating enzyme. Lett.Drug Des.Discov.
7
57 PMID: 20396627
Keywords: PYR 41, supplier, PYR41, ubiquitin-activating, enzyme, E1, inhibitors, inhibits, ubiquitylation, post-translational, modifications, proteasomal, proteasome, sumoylation, sumo, ubiquitin, Ubiquitin-activating, Enzyme, E1, Post-translational, Modifications, Ubiquitin-activating, Enzyme, E1,
Tocris
Bioscience
產(chǎn)品貨號:9364.0