Tocris/PYZD 4409/4994/50/50 mg
克隆和表達
商品編號
4994/50
品牌
Tocris
公司
Bio-Techne Corporation
公司分類(lèi)
Ligases
Size
50 mg
商品信息
Description:
Ubiquitin-activating enzyme (E1) inhibitor
Chemical Name:
1-(3-Chloro-4-fluorophenyl)-4-[(5-nitro-2-furanyl)methylene]-3,5-pyrazolidinedione
Purity:
≥98% (HPLC)
BIOLOG
ical Activity
Technical Data
Solubility
Calculators
Datasheets
References
BIOLOG
ical Activity
Ubiquitin-activating enzyme (E1) inhibitor. Blocks degradation of p53 and cyclin D3. Inhibits NF-
κ
B activation and induces cell death associated with ER stress. Displays antitumor effects in a mouse model of leukemia.
Technical Data
M. Wt
351.67
Formula
C
14
H
7
ClFN
3
O
5
Storage
Store at -20°C
Purity
≥98% (HPLC)
CAS Number
423148-78-1
PubChem ID
60111983
InChI Key
MSYMKEYWUWVZQY-TWGQIWQCSA-N
Smiles
FC(C=C3)=C(Cl)C=C3N(C(/C1=CC2=CC=C([N+]([O-])=O)O2)=O)NC1=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All
Tocris
products are intended for laboratory research use only.
Solubility Data
Solvent
Max Conc. mg/mL
Max Conc. mM
Solubility
DMSO
35.17
100
Preparing Stock Solutions
The following data is based on the
product
molecular weight
351.67
. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass
1 mg
5 mg
10 mg
1 mM
2.84 mL
14.22 mL
28.44 mL
5 mM
0.57 mL
2.84 mL
5.69 mL
10 mM
0.28 mL
1.42 mL
2.84 mL
50 mM
0.06 mL
0.28 mL
0.57 mL
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Product Datasheets
Certificate of Analysis / Product Datasheet
Safety Datasheet
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References
References are publications that support the products'
BIOLOG
ical activity.
Xu
et al
(2010) The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma. Blood
115
2251 PMID: 20075161
Keywords: PYZD 4409, supplier, PYZD4409, ubiquitin-activating, enzyme, E1, inhibitors, inhibits, ubiquitylation, ubiquitin, Ubiquitin-activating, Enzyme, E1, Post-translational, Modifications, Ubiquitin-activating, Enzyme, E1,
Tocris
Bioscience
產(chǎn)品貨號:9140.0