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商品編號


4375/10



品牌


Tocris



公司


Bio-Techne Corporation



公司分類(lèi)


Ligases



Size

10 mg

商品信息

Description:
Selective inhibitor of E3 ubiquitin ligase

Chemical Name:
9
H
-Indeno[1,2-
e
][1,2,5]ox
ADI
azolo[3,4-
b
]pyrazin-9-one

Purity:
≥98% (HPLC)


BIOLOG
ical Activity Technical Data Solubility Calculators Datasheets References


BIOLOG
ical Activity

Selective inhibitor of a yeast SCF family E3 ubiquitin ligase (SCF
Met30
)
in vitro
and
in vivo
. Induces the expression of MET genes; blocks cell proliferation. Enhancer of rapamycin (Cat. No. 1292).



Technical Data



M. Wt

224.18



Formula

C
11
H
4
N
4
O
2




Storage

Store at +4°C



Purity

≥98% (HPLC)



CAS Number

67200-34-4



PubChem ID

568763



InChI Key

SFSSAKVWCKFRHE-UHFFFAOYSA-N



Smiles

O=C4C2=NC1=NON=C1N=C2C3=CC=CC=C34



The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All
Tocris
products are intended for laboratory research use only.



Solubility Data




Solvent

Max Conc. mg/mL

Max Conc. mM



Solubility



DMSO

16.81

75





Preparing Stock Solutions

The following data is based on the
product
molecular weight
224.18
. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.



Concentration / Solvent Volume / Mass

1 mg

5 mg

10 mg



1 mM

4.46 mL

22.3 mL

44.61 mL



5 mM

0.89 mL

4.46 mL

8.92 mL



10 mM

0.45 mL

2.23 mL

4.46 mL



50 mM

0.09 mL

0.45 mL

0.89 mL






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Product Datasheets


Certificate of Analysis / Product Datasheet


Safety Datasheet

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References

References are publications that support the products'
BIOLOG
ical activity.


Aghajanyy

et al
(2010) Chemical genetics of TOR identifies an SCF family E3 ubiquitin ligase inhibitor. Nat.Biotechnol.
28
738 PMID: 20581845




Keywords: SMER 3, supplier, SMER3, ubiquitin, E3, ligase, inhibitors, inhibits, Ub, ligases, small-molecule, enhancers, rapamycin, SCF, family, Ubiquitin, E3, Ligases, Ubiquitin, E3, Ligases,
Tocris
Bioscience