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商品編號


5332/10



品牌


Tocris



公司


Bio-Techne Corporation



公司分類(lèi)


Ligases



Size

10 mg

商品信息

Description:
High affinity MDM2 inhibitor

Chemical Name:
6-Methoxy-1-(1-naphthalenyl)-9
H
-pyrido[3,4-
b
]indole

Purity:
≥98% (HPLC)


BIOLOG
ical Activity Technical Data Solubility Calculators Datasheets References


BIOLOG
ical Activity

High affinity MDM2 inhibitor (K
i
= 28 nM); directly binds MDM2. Inhibits MDM2 expression and induces MDM2 autoubiquitination and proteasomal degradation. Attenuates growth of breast cancer xenograft tumors. Cell permeable.



Compound Libraries

SP 141 is also offered as part of the
Tocris
creen Plus. Find out more about compound libraries available from
Tocris
.



Technical Data



M. Wt

324.38



Formula

C
22
H
16
N
2
O



Storage

Store at +4°C



Purity

≥98% (HPLC)



CAS Number

1253491-42-7



PubChem ID

59620153



InChI Key

AABFWJDLCCDJJN-UHFFFAOYSA-N



Smiles

COC1=CC=C(NC2=C3C=CN=C2C4=CC=CC5=C4C=CC=C5)C3=C1



The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All
Tocris
products are intended for laboratory research use only.



Solubility Data




Solvent

Max Conc. mg/mL

Max Conc. mM



Solubility



DMSO

32.44

100



ethanol

32.44

100





Preparing Stock Solutions

The following data is based on the
product
molecular weight
324.38
. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.



Concentration / Solvent Volume / Mass

1 mg

5 mg

10 mg



1 mM

3.08 mL

15.41 mL

30.83 mL



5 mM

0.62 mL

3.08 mL

6.17 mL



10 mM

0.31 mL

1.54 mL

3.08 mL



50 mM

0.06 mL

0.31 mL

0.62 mL






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Product Datasheets


Certificate of Analysis / Product Datasheet


Safety Datasheet

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References

References are publications that support the products'
BIOLOG
ical activity.


Wang

et al
(2014) The pyrido[b]indole MDM2 inhibitor SP-141 exerts potent therapeutic effects in breast cancer models. Nat.Commun.
5
5086 PMID: 25271708




Keywords: SP 141, supplier, SP141, High, affinity, MDM2, inhibitors, inhibits, antitumor, antitumour, Mouse, double, minute, 2, homolog, Ubiquitin, E3, Ligases, p53, Ubiquitin, E3, Ligases,
Tocris
Bioscience