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商品編號


4506/50



品牌


Tocris



公司


Bio-Techne Corporation



公司分類(lèi)


Ligases



Size

50 mg

商品信息

Description:
Ubiquitin ligase APC/C inhibitor; promotes Cdc20 autoubiquitination

Chemical Name:

N
2
-[(4-Methylphenyl)sulfonyl]-
L
-arginine methyl ester hydrochloride

Purity:
≥99% (HPLC)


BIOLOG
ical Activity Technical Data Solubility Calculators Datasheets References


BIOLOG
ical Activity

Competitive inhibitor of the ubiquitin ligase anaphase-promoting complex/cyclosome (APC/C); promotes Cdc20 autoubiquitination. Inhibits cyclin proteolysis in mitotic
Xenopus
oocyte extracts (IC
50
= 12
μ
M) and blocks cyclin degradation in interphase extract.



Technical Data



M. Wt

378.87



Formula

C
14
H
22
N
4
O
4
S.HCl



Storage

Store at -20°C



Purity

≥99% (HPLC)



CAS Number

1784-03-8



PubChem ID

2723792



InChI Key

JIQFFACVQXXHMY-YDALLXLXSA-N



Smiles

NC(NCCC[C@H](NS(C1=CC=C(C)C=C1)(=O)=O)C(OC)=O)=N.Cl



The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All
Tocris
products are intended for laboratory research use only.



Solubility Data




Solvent

Max Conc. mg/mL

Max Conc. mM



Solubility



DMSO

37.89

100



water

37.89

100





Preparing Stock Solutions

The following data is based on the
product
molecular weight
378.87
. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.



Concentration / Solvent Volume / Mass

1 mg

5 mg

10 mg



1 mM

2.64 mL

13.2 mL

26.39 mL



5 mM

0.53 mL

2.64 mL

5.28 mL



10 mM

0.26 mL

1.32 mL

2.64 mL



50 mM

0.05 mL

0.26 mL

0.53 mL






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Product Datasheets


Certificate of Analysis / Product Datasheet


Safety Datasheet

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References

References are publications that support the products'
BIOLOG
ical activity.


Zeng

et al
(2010) Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage. Cancer Cell.
18
382 PMID: 20951947


Zeng & King
(2012) An APC/C inhibitor st
ABI
lizes cyclin B1 by prematurely terminating ubiquitination. Nat.Chem.Biol.
8
383 PMID: 22366722




Keywords: TAME hydrochloride, supplier, ubiquitin, ligase, anaphase-promoting, complex/cyclosome, APC, inhibits, inhibitors, competitive, mitotic, arrest, cyclin, st
ABI
lization, TAME, hydrochloride, HCl, Ubiquitin, E3, Ligases, Mitosis, Ubiquitin, E3, Ligases,
Tocris
Bioscience