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商品編號


5049/10



品牌


Tocris



公司


Bio-Techne Corporation



公司分類(lèi)


Polymerases



Size

10 mg

商品信息

Description:
Potent tankyrase inhibitor

Chemical Name:
3-(4-Methoxyphenyl)-5-[[[4-(4-methoxyphenyl)-5-methyl-4
H
-1,2,4-triazol-3-yl]thio]methyl]-1,2,4-ox
ADI
azole

Purity:
≥98% (HPLC)


BIOLOG
ical Activity Technical Data Solubility Calculators Datasheets References


BIOLOG
ical Activity

Dual tankyrase (TNKS) inhibitor (K
d
values are 79 and 28 nM for TNKS1 and TNKS2 respectively, IC
50
= 33 nM for TNKS2) that is devoid of activity at PARP1 and PARP2 (IC
50
>19
μ
M). Inhibits Wnt signaling and st
ABI
lizes Axin2 levels.



Technical Data



M. Wt

409.46



Formula

C
20
H
19
N
5
O
3
S



Storage

Store at +4°C



Purity

≥98% (HPLC)



CAS Number

865565-29-3



PubChem ID

16013184



InChI Key

LQZSHPITKSPDLC-UHFFFAOYSA-N



Smiles

CC1=NN=C(SCC3=NC(C4=CC=C(OC)C=C4)=NO3)N1C2=CC=C(OC)C=C2



The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All
Tocris
products are intended for laboratory research use only.



Solubility Data




Solvent

Max Conc. mg/mL

Max Conc. mM



Solubility



DMSO

40.95

100





Preparing Stock Solutions

The following data is based on the
product
molecular weight
409.46
. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.



Concentration / Solvent Volume / Mass

1 mg

5 mg

10 mg



1 mM

2.44 mL

12.21 mL

24.42 mL



5 mM

0.49 mL

2.44 mL

4.88 mL



10 mM

0.24 mL

1.22 mL

2.44 mL



50 mM

0.05 mL

0.24 mL

0.49 mL






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Product Datasheets


Certificate of Analysis / Product Datasheet


Safety Datasheet

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References

References are publications that support the products'
BIOLOG
ical activity.


Shultz

et al
(2012) [1,2,4]Triazole-3-ylsulfanylmethyl)-3-phenyl-[1,2,4]ox
ADI
azoles: antago
NIST
s of the wnt pathway that inhibit tankyrases 1 and 2 via novel adenosine pocket binding. J.Med.Chem.
55
1127 PMID: 22260203




Keywords: TC-E 5001, supplier, TC-E5001, TNKS1, TNKS2, tankyrase, inhibitors, inhibits, wnt, signaling, signalling, Poly(ADP-ribose), Polymerase, Tankyrase, Tankyrase,
Tocris
Bioscience