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商品編號


4253/50



品牌


Tocris



公司


Bio-Techne Corporation



公司分類(lèi)


Polymerases



Size

50 mg

商品信息

Description:
Inhibitor of human telomerase

Chemical Name:
5,10,15,20-Tetrakis(1-methylpyridinium-4-yl)porphyrin tetra(
p
-toluenesulfonate)

Purity:
≥95% (HPLC)


BIOLOG
ical Activity Technical Data Solubility Calculators Datasheets References


BIOLOG
ical Activity

Cationic porphyrin; inhibits human telomerase. Stacks with G tetrads to st
ABI
lize quadruplex DNA. Inhibits cell proliferation and induces cell death in three myeloma cell lines. Activity results in telomere shortening at concentrations between 1 and 5
μ
M.



Technical Data



M. Wt

1363.6



Formula

C
72
H
66
N
8
O
12
S
4




Storage

Store at +4°C



Purity

≥95% (HPLC)



CAS Number

36951-72-1



PubChem ID

11979833



InChI Key

AKZFRMNXBLFDNN-UHFFFAOYSA-K



Smiles

C[N+](C=C9)=CC=C9/C(C2=CC=C(/C(C8=CC=[N+](C)C=C8)=C3/C=CC4=N3)N2)=C1N=C(/C(C7=CC=[N+](C)C=C7)=C(N6)/C=CC6=C4/C5=CC=[N+](C)C=C5)C=C1.CC%10=CC=C(S(=O)([O-])=O)C=C%10.CC%11=CC=C(S(=O)([O-])=O)C=C%11.CC%12=CC=C(S(=O)([O-])=O)C=C%12.CC%13=CC=C(S(=O)([O-])=O)C=C%13



The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All
Tocris
products are intended for laboratory research use only.



Solubility Data




Solvent

Max Conc. mg/mL

Max Conc. mM



Solubility



water

68.18

50





Preparing Stock Solutions

The following data is based on the
product
molecular weight
1363.6
. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.



Concentration / Solvent Volume / Mass

1 mg

5 mg

10 mg



1 mM

0.73 mL

3.67 mL

7.33 mL



5 mM

0.15 mL

0.73 mL

1.47 mL



10 mM

0.07 mL

0.37 mL

0.73 mL



50 mM

0.01 mL

0.07 mL

0.15 mL






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Product Datasheets


Certificate of Analysis / Product Datasheet


Safety Datasheet

Select another language:



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View SDS





References

References are publications that support the products'
BIOLOG
ical activity.


Rha

et al
(2000) Effect of telomere and telomerase interactive agents on human tumor and normal cell lines. Clin.Cancer Res.
6
987 PMID: 10741725


Shammas

et al
(2003) Telomerase inhibition and cell growth arrest by G-quadruplex interactive agent in multiple myeloma. Mol.Cancer Ther.
2
825 PMID: 14555701


Wheelhouse

et al
(1998) Cationic porphyrins as telomerase inhibitors: the interaction of tetra-(
N
-methyl-4-pyridyl)porphine with quadruplex DNA. J.Am.Chem.Soc.
120
3261 PMID:


Shi

et al
(2001) Quadruplex-interactive agents as telomerase inhibitors: synthesis of porphyrins and structure-activity relationship for the inhibition of telomerase. J.Med.Chem.
474
4509 PMID:




Keywords: TMPyP4 tosylate, supplier, TMPyP4, telomerase, inhibitors, inhibits, g, tetrads, quadruplex, DNA, telomeres, Telomerase, Telomerase,
Tocris
Bioscience